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公开(公告)号：US20070237773A1
公开(公告)日：2007-10-11
申请号：US11625386
申请日：2007-01-22
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K14/4703 , C07K16/18
摘要： The invention relates to a novel costimulatory pathway mediated by a member of the semaphorin protein family, Sema4A, which is selectively expressed on the surface of dendritic cells. In addition, the invention relates to the use of Sema4A protein and protein derivatives in a method for the identification of immunomodulatory substances and to therapeutic applications making use thereof.
摘要翻译： 本发明涉及由树突状细胞表面选择性表达的信号素蛋白家族成员Sema4A介导的新型共刺激途径。 此外，本发明涉及Sema4A蛋白质和蛋白质衍生物在鉴定免疫调节物质的方法中的用途以及利用其的治疗应用。
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公开(公告)号：US20080317766A1
公开(公告)日：2008-12-25
申请号：US12128658
申请日：2008-05-29
IPC分类号： A61K39/395 , C07K14/435 , A61K39/00 , C07K16/00
CPC分类号： C07K14/4703 , C07K16/18
摘要： The invention relates to a novel costimulatory pathway mediated by a member of the semaphorin protein family, Sema4A, which is selectively expressed on the surface of dendritic cells. In addition, the invention relates to the use of Sema4A protein and protein derivatives in a method for the identification of immunomodulatory substances and to therapeutic applications making use thereof.
摘要翻译： 本发明涉及由树突状细胞表面选择性表达的信号素蛋白家族成员Sema4A介导的新型共刺激途径。 此外，本发明涉及Sema4A蛋白质和蛋白质衍生物在鉴定免疫调节物质的方法中的用途以及利用其的治疗应用。
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3.发明申请Compositions for Inhibiting plexin-A1-DAP12 interactions and Methods of Treating Inflammatory, Autoimmune or Bone Resorption Diseases Using the Same 审中-公开用于抑制plexin-A1-DAP12相互作用的组合物和使用它们治疗炎症，自身免疫或骨吸收疾病的方法公开(公告)号：US20080045443A1
公开(公告)日：2008-02-21
申请号：US11550166
申请日：2006-10-17
CPC分类号： C07K16/18 , A61K38/177 , A61K38/1774 , G01N33/5008 , G01N2333/4704 , G01N2500/02
摘要： Disclosed are compositions and methods of treating an inflammatory, autoimmune or bone resorption disease by inhibiting plexin-A1-DAP12 interaction, plexin-A1-Trem-2 interaction or DAP12-Trem-2 interaction.
摘要翻译： 公开了通过抑制plexin-A1-DAP12相互作用，plexin-A1-Trem-2相互作用或DAP12-Trem-2相互作用来治疗炎症，自身免疫或骨吸收疾病的组合物和方法。
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4.发明授权Compositions for inhibiting Sema7A and VLA-1 interaction and the methods of using the same 有权用于抑制Sema7A和VLA-1相互作用的组合物及其使用方法公开(公告)号：US07462461B2
公开(公告)日：2008-12-09
申请号：US11550184
申请日：2006-10-17
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/2842
摘要： Disclosed are compositions and methods of treating a cytokine mediated diseases by inhibiting Sema7A and VLA-1 interaction.
摘要翻译： 公开了通过抑制Sema7A和VLA-1相互作用来治疗细胞因子介导的疾病的组合物和方法。
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5.发明申请METHODS OF IDENTIFYING COMPOUNDS CAPABLE OF MODULATING T CELL IMMUNE RESPONSES INVOLVING SEMA4A PROTEIN 审中-公开鉴定涉及SEMA4A蛋白的调节T细胞免疫应答的化合物的方法公开(公告)号：US20070160604A1
公开(公告)日：2007-07-12
申请号：US11668121
申请日：2007-01-29
IPC分类号： A61K39/395 , G01N33/567
CPC分类号： C07K14/4703 , C07K16/18
摘要： The invention relates to a novel costimulatory pathway mediated by a member of the semaphorin protein family, Sema4A, which is selectively expressed on the surface of dendritic cells. In addition, the invention relates to the use of Sema4A protein and protein derivatives in a method for the identification of immunomodulatory substances and to therapeutic applications making use thereof.
摘要翻译： 本发明涉及由树突状细胞表面选择性表达的信号素蛋白家族成员Sema4A介导的新型共刺激途径。 此外，本发明涉及Sema4A蛋白质和蛋白质衍生物在鉴定免疫调节物质的方法中的用途以及利用其的治疗应用。
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6.发明申请THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASES OR ALLERGY, AND METHOD FOR SCREENING FOR THE THERAPEUTIC AGENT 审中-公开用于自身免疫性疾病或过敏症的治疗剂，以及用于治疗药物的筛选方法公开(公告)号：US20120322085A1
公开(公告)日：2012-12-20
申请号：US13508192
申请日：2010-11-05
申请人： Atsushi Kumanogoh
发明人： Atsushi Kumanogoh
IPC分类号： C07K16/28 , C07K14/705 , G01N21/76 , C12N5/0784 , G01N33/566 , C07K16/18 , C07K19/00
CPC分类号： G01N33/566 , C07K16/18 , C07K16/2863 , C07K2317/34 , G01N33/53 , G01N2500/04
摘要： Disclosed is a therapeutic agent for treating a cellular immune disease, comprising as an active ingredient a substance that inhibits binding between Sema3A and a Neuropilin-1/Plexin-A1 heteroreceptor. The substance includes, for example, a Sema3A neutralizing antibody, a Neuropilin-1 neutralizing antibody, or a soluble Neuropilin-1 or derivative thereof. Also disclosed is a method for screening a therapeutic agent for treating a cellular immune disease utilizing a signal generated by the interactions of Neuropilin-1, Plexin-A1 and Sema3A as a marker.
摘要翻译： 公开了用于治疗细胞免疫疾病的治疗剂，其包含抑制Sema3A与神经蛋白-1 / Plexin-A1异型受体结合的物质作为活性成分。 该物质包括例如Sema3A中和抗体，Neuropilin-1中和抗体或可溶性神经蛋白-1或其衍生物。 还公开了利用由Neuropilin-1，Plexin-A1和Sema3A的相互作用产生的信号作为标记来筛选治疗细胞免疫疾病的治疗剂的方法。
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公开(公告)号：US20080058257A1
公开(公告)日：2008-03-06
申请号：US11741133
申请日：2007-04-27
CPC分类号： C07K14/4703 , C07K16/18
摘要： The invention relates to a novel costimulatory pathway mediated by a member of the semaphorin protein family, Sema4A, which is selectively expressed on the surface of dendritic cells. In addition, the invention relates to the use of Sema4A protein and protein derivatives in a method for the identification of immunomodulatory substances and to therapeutic applications making use thereof.
摘要翻译： 本发明涉及由树突状细胞表面选择性表达的信号素蛋白家族成员Sema4A介导的新型共刺激途径。 此外，本发明涉及Sema4A蛋白质和蛋白质衍生物在鉴定免疫调节物质的方法中的用途以及利用其的治疗应用。
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8.发明申请Compositions for Inhibiting Sema7A and VLA-1 Interaction and the Methods of Using the Same 有权用于抑制Sema7A和VLA-1相互作用的组合物及其使用方法公开(公告)号：US20070264263A1
公开(公告)日：2007-11-15
申请号：US11550184
申请日：2006-10-17
IPC分类号： A61K39/395 , C07K16/24 , G01N33/53
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/2842
摘要： Disclosed are compositions and methods of treating a cytokine mediated diseases by inhibiting Sema7A and VLA-1 interaction.
摘要翻译： 公开了通过抑制Sema7A和VLA-1相互作用来治疗细胞因子介导的疾病的组合物和方法。
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