发明申请
- 专利标题： Thiazole inhibitors targeting resistant kinase mutations
- 专利标题（中）： 噻唑抑制剂靶向抗性激酶突变
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申请号： US11591252申请日： 2006-10-31
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公开(公告)号： US20070161645A1公开(公告)日： 2007-07-12
- 发明人: Glenn Noronha , Jianguo Cao , Binqi Zeng , Chi Mak , Andrew McPherson , Joel Renick , Ved Pathak , Chun Chow , Moorthy Palanki , Richard Soll , Daniel Lohse , John Hood , Elena Dneprovskaia
- 申请人： Glenn Noronha , Jianguo Cao , Binqi Zeng , Chi Mak , Andrew McPherson , Joel Renick , Ved Pathak , Chun Chow , Moorthy Palanki , Richard Soll , Daniel Lohse , John Hood , Elena Dneprovskaia
- 申请人地址： US CA San Diego
- 专利权人： TargeGen, Inc.
- 当前专利权人： TargeGen, Inc.
- 当前专利权人地址： US CA San Diego
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; A61K31/496 ; A61K31/454 ; A61K31/427 ; A61K31/428 ; C07D417/14
摘要：
A compound is provided, having the general structure (A): wherein A is an aryl or heteroaryl group, Y is a hydrophbic linking moiety, and L is a substitutent. The compound (A) can be used for treatment of various angiogenic-associated or hematologic disorders, such as myeloproliferative disorders in patients who do not respond to kinase-inhibition therapy that comprises administering currently used medications.
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