A bio-signal detection device and a method of managing the health of a user is used with a health management system. The device includes a main body having palm support portions formed on the top of both sides thereof, a sensing unit formed on at least one of the palm support portions to detect a bio-signal of a user and including electrodes, and an operation unit receiving a signal from the sensing unit to operate. The method includes maintaining a first and second database including inquiry information and information on the normal physical condition of a user; comparing a measured present physical condition with the normal physical condition and detecting a changed item associated with the physical condition of the user; outputting lifestyle inquiry information associated with the detected changed item; receiving a reply to the outputted lifestyle inquiry information; analyzing a health condition of the user; and reporting health condition information.