发明申请
US20070185020A1 Methods and compositions for treating disorders of the extracellular matrix
审中-公开
用于治疗细胞外基质紊乱的方法和组合物
- 专利标题： Methods and compositions for treating disorders of the extracellular matrix
- 专利标题（中）： 用于治疗细胞外基质紊乱的方法和组合物
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申请号： US10562778申请日： 2004-06-30
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公开(公告)号： US20070185020A1公开(公告)日： 2007-08-09
- 发明人: Chai Zhonglin , Mark Cooper , Zemin Cao
- 申请人： Chai Zhonglin , Mark Cooper , Zemin Cao
- 优先权： AU2003903363 20030701
- 国际申请： PCT/AU04/00873 WO 20040630
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; A61K48/00 ; G01N33/567
摘要：
The present invention provides a method for altering the level of an extracellular matrix (ECM) protein produced by a cell, the method including modulating expression or activity of a cell division auto antigen (CDA). The Applicants have surprisingly found that a CDA is involved in a pathway that controls the level of ECM protein produced by mammalian cells. The invention has relevance to a number of ECM-related disorders such as renal fibrosis and atherosclerosis.