公开(公告)号：US20070185020A1

公开(公告)日：2007-08-09

申请号：US10562778

申请日：2004-06-30

申请人： Chai Zhonglin ,  Mark Cooper ,  Zemin Cao

发明人： Chai Zhonglin ,  Mark Cooper ,  Zemin Cao

IPC分类号： A61K38/17 ,  A61K48/00 ,  G01N33/567

CPC分类号： C07K14/4702 ,  A01K2267/03 ,  G01N33/6887 ,  G01N2500/00 ,  G01N2800/085 ,  G01N2800/10 ,  G01N2800/323

摘要： The present invention provides a method for altering the level of an extracellular matrix (ECM) protein produced by a cell, the method including modulating expression or activity of a cell division auto antigen (CDA). The Applicants have surprisingly found that a CDA is involved in a pathway that controls the level of ECM protein produced by mammalian cells. The invention has relevance to a number of ECM-related disorders such as renal fibrosis and atherosclerosis.

摘要翻译： 本发明提供了改变由细胞产生的细胞外基质（ECM）蛋白的水平的方法，所述方法包括调节细胞分裂自身抗原（CDA）的表达或活性。 申请人惊奇地发现，CDA参与控制哺乳动物细胞产生的ECM蛋白水平的途径。 本发明与许多ECM相关的疾病如肾纤维化和动脉粥样硬化有关。