发明申请
- 专利标题: Purification of progesterone receptor modulators
- 专利标题(中): 孕酮受体调节剂的纯化
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申请号: US11713971申请日: 2007-03-05
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公开(公告)号: US20070213526A1公开(公告)日: 2007-09-13
- 发明人: Mahmut Levent , Panolil Raveendranath , Bogdan Wilk , Donald Carl Boop , Marinus Cornelis Hofman
- 申请人: Mahmut Levent , Panolil Raveendranath , Bogdan Wilk , Donald Carl Boop , Marinus Cornelis Hofman
- 申请人地址: US NJ Madison
- 专利权人: Wyeth
- 当前专利权人: Wyeth
- 当前专利权人地址: US NJ Madison
- 主分类号: C07D279/16
- IPC分类号: C07D279/16 ; C07D265/12 ; C07D209/54
摘要:
Processes are provided for purifying a compound of the structure: wherein, A, B, T, Q and R1 are defined herein, and wherein the process includes dissolving the compound of formula I in a solution containing acetone, water and a base at about 30° C.; filtering the solution containing the compound of formula I at about 30° C.; and precipitating the purified compound of formula I by adjusting the filtered solution to an acidic pH. Desirably, the compound of formula I is 5-(2-thioxospiro[cyclohexane-1,3-[3H]indol]-5-yl)-1-methylpyrrole-2-carbonitrile or tanaproget.
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