Invention Application
- Patent Title: C-MET MODULATORS AND METHOD OF USE
- Patent Title (中): C-MET调制器及其使用方法
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Application No.: US11753462Application Date: 2007-05-24
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Publication No.: US20070225307A1Publication Date: 2007-09-27
- Inventor: Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wie Xu
- Applicant: Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wie Xu
- Applicant Address: US CA South San Francisco
- Assignee: EXELIXIS, INC.
- Current Assignee: EXELIXIS, INC.
- Current Assignee Address: US CA South San Francisco
- Main IPC: A61K31/517
- IPC: A61K31/517 ; A61K31/4709 ; A61K31/4704 ; C07D401/02 ; C07D403/02 ; C07D417/02
Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
Public/Granted literature
- US08178532B2 c-Met modulators and method of use Public/Granted day:2012-05-15
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