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公开(公告)号：US20070225307A1
公开(公告)日：2007-09-27
申请号：US11753462
申请日：2007-05-24
申请人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wie Xu
发明人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wie Xu
IPC分类号： A61K31/517 , A61K31/4709 , A61K31/4704 , C07D401/02 , C07D403/02 , C07D417/02
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US20070032515A1
公开(公告)日：2007-02-08
申请号：US10565657
申请日：2004-07-23
申请人： Neel Anand , Charles Blazey , Owen Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Curtis , Larisa Dubenko , Abigail Kennedy , Richard Khoury , Angie Kim , Jean-Claire Manalo , Csaba Peto , Kenneth Rice , Tsze Tsang
发明人： Neel Anand , Charles Blazey , Owen Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Curtis , Larisa Dubenko , Abigail Kennedy , Richard Khoury , Angie Kim , Jean-Claire Manalo , Csaba Peto , Kenneth Rice , Tsze Tsang
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04 , C07D491/147 , C07D519/00
摘要： The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.
摘要翻译： 本发明包括包含作为ALK抑制剂的化合物的化合物和药物组合物。 本发明还包括使用化合物和组合物来治疗由ALK介导的疾病，包括诸如癌症，免疫学障碍，心血管疾病和其它退行性疾病的疾病的方法。
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公开(公告)号：US20070244116A1
公开(公告)日：2007-10-18
申请号：US11753503
申请日：2007-05-24
申请人： LYNNE BANNEN , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
发明人： LYNNE BANNEN , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
IPC分类号： A61K31/47 , A61K31/16 , A61K31/517 , C07C229/40 , C07D215/22 , C07D239/94 , C07D413/12 , C07D239/88 , C07C233/59 , A61K31/5355 , A61K31/196
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US20070275952A1
公开(公告)日：2007-11-29
申请号：US10549300
申请日：2004-03-19
申请人： Lynne Bannen , S. Brown , Wei Cheng , Vasu Jammalamadaka , John Nuss , Morrison Mac , Jason Parks , Matthew Williams , Wei Xu , Atwood Cheung , Lisa Dalrymple , Sergey Epshteyn , Mohamed Ibrahim , James Leahy , Gary Lewis , Robin Noguchi , Larry Mann , Brian Ridway , Joan Sangalang , Kevin Schnepp , Xian Shi , Richard Khoury
发明人： Lynne Bannen , S. Brown , Wei Cheng , Vasu Jammalamadaka , John Nuss , Morrison Mac , Jason Parks , Matthew Williams , Wei Xu , Atwood Cheung , Lisa Dalrymple , Sergey Epshteyn , Mohamed Ibrahim , James Leahy , Gary Lewis , Robin Noguchi , Larry Mann , Brian Ridway , Joan Sangalang , Kevin Schnepp , Xian Shi , Richard Khoury
IPC分类号： A61K31/41 , A61K31/44 , A61K31/445 , A61K31/497 , A61K31/535 , A61K31/551 , A61P35/00 , C07D243/08 , C07D285/10 , C07D401/14 , C07D413/00 , C07D417/02 , C12N5/00 , C12Q1/00
CPC分类号： A61K31/496 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。
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公开(公告)号：US20070054928A1
公开(公告)日：2007-03-08
申请号：US11586751
申请日：2006-10-26
申请人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
发明人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
IPC分类号： A61K31/517 , A61K31/4709 , C07D403/02 , C07D401/02
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节激酶受体，特别是c-Met，KDR，c-Kit，flt-3和flt-4，与细胞活性变化相关的信号转导途径的喹啉和喹啉 含有这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US20060199820A1
公开(公告)日：2006-09-07
申请号：US10518110
申请日：2003-06-11
申请人： Lynne Bannen , Erick Co , Vasu Jammalamadaka , John Nuss , Moon Hwan Kim , Donna Le , Amy Lew , Morrison Mac , Shumeye Mamo , Richard Khoury , Zhaoyang Wen , Wei Xu
发明人： Lynne Bannen , Erick Co , Vasu Jammalamadaka , John Nuss , Moon Hwan Kim , Donna Le , Amy Lew , Morrison Mac , Shumeye Mamo , Richard Khoury , Zhaoyang Wen , Wei Xu
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/495 , C07D413/02 , C07D403/02
CPC分类号： C07D241/04 , C07C309/87 , C07D213/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/06
摘要： The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
摘要翻译： 本发明提供了用于抑制ADAM-10蛋白质的化合物，具有选择性对MMP-1。 这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。 相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。
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