发明申请
US20070232568A1 Carbohydrate Composition and Its Use for the Preparation of a Medicament for Treating or Preventing Pulmonary Inflammation or Acute Respiration Distress Syndrome
审中-公开
碳水化合物组合物及其用于制备治疗或预防肺部炎症或急性呼吸窘迫综合征的药物的用途
- 专利标题: Carbohydrate Composition and Its Use for the Preparation of a Medicament for Treating or Preventing Pulmonary Inflammation or Acute Respiration Distress Syndrome
- 专利标题(中): 碳水化合物组合物及其用于制备治疗或预防肺部炎症或急性呼吸窘迫综合征的药物的用途
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申请号: US10572240申请日: 2004-09-20
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公开(公告)号: US20070232568A1公开(公告)日: 2007-10-04
- 发明人: Klaske van Norren , Eduard van Hoorn , Robert Hageman , Kelly Lamb
- 申请人: Klaske van Norren , Eduard van Hoorn , Robert Hageman , Kelly Lamb
- 申请人地址: NL Zoetermeer NL-2712 HM
- 专利权人: N.V. Nutricia
- 当前专利权人: N.V. Nutricia
- 当前专利权人地址: NL Zoetermeer NL-2712 HM
- 优先权: EP03077972.2 20030919
- 国际申请: PCT/NL04/00649 WO 20040920
- 主分类号: A61K31/70
- IPC分类号: A61K31/70 ; A23L1/30 ; A61K31/7004 ; A61K31/715 ; A61P11/00 ; A61K31/7016 ; A23L1/305
摘要:
One aspect of the present invention is concerned with a method of treating or preventing pulmonary inflammation as a complication ensuing from physical trauma, bacteraemia or viral inflection, said method comprising enterally administering at least one or more glutathione promoters selected from: −0.3-20 g, preferably 0.5-5 g pyruvate equivalents; −0.1-5 g, preferably 0.2-2 g oxaloacetate equivalents; −0.01-1 g, preferably 0.02-0.5 g lipoic acid equivalents; and at least 20 g of digestible water soluble carbohydrates, in the form of an aqueous liquid composition containing at least 10 g/l of said digestible water soluble carbohydrates. Another aspect of the invention relates to an aqueous liquid composition suitable for enteral administration containing: 2 to 20 wt. % digestible dissolved carbohydrates; two or more glutathione promoters selected from: 0.5 to 50 g/l pyruvate equivalents; 0.05 to 20 g/l oxaloacetate equivalents; 0.05 to 5 g/l cystein equivalents; and at least 45 wt % water.
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