发明申请
US20070232568A1 Carbohydrate Composition and Its Use for the Preparation of a Medicament for Treating or Preventing Pulmonary Inflammation or Acute Respiration Distress Syndrome 审中-公开
碳水化合物组合物及其用于制备治疗或预防肺部炎症或急性呼吸窘迫综合征的药物的用途

Carbohydrate Composition and Its Use for the Preparation of a Medicament for Treating or Preventing Pulmonary Inflammation or Acute Respiration Distress Syndrome
摘要:
One aspect of the present invention is concerned with a method of treating or preventing pulmonary inflammation as a complication ensuing from physical trauma, bacteraemia or viral inflection, said method comprising enterally administering at least one or more glutathione promoters selected from: −0.3-20 g, preferably 0.5-5 g pyruvate equivalents; −0.1-5 g, preferably 0.2-2 g oxaloacetate equivalents; −0.01-1 g, preferably 0.02-0.5 g lipoic acid equivalents; and at least 20 g of digestible water soluble carbohydrates, in the form of an aqueous liquid composition containing at least 10 g/l of said digestible water soluble carbohydrates. Another aspect of the invention relates to an aqueous liquid composition suitable for enteral administration containing: 2 to 20 wt. % digestible dissolved carbohydrates; two or more glutathione promoters selected from: 0.5 to 50 g/l pyruvate equivalents; 0.05 to 20 g/l oxaloacetate equivalents; 0.05 to 5 g/l cystein equivalents; and at least 45 wt % water.
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