公开(公告)号：US20070202194A1

公开(公告)日：2007-08-30

申请号：US11741547

申请日：2007-04-27

申请人： Amanda Kiliaan ,  Robert Hageman

发明人： Amanda Kiliaan ,  Robert Hageman

IPC分类号： A61K33/34 ,  A61K31/495 ,  A61K31/535 ,  A61K33/30

CPC分类号： A61K31/685 ,  A23L33/105 ,  A23L33/115 ,  A23L33/15 ,  A23L33/16 ,  A23V2002/00 ,  A61K31/14 ,  A61K31/194 ,  A61K31/20 ,  A61K31/202 ,  A61K31/205 ,  A61K31/355 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/683 ,  A61K33/30 ,  A61K33/34 ,  A61K36/16 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/1842 ,  A23V2250/7052 ,  A23V2250/706 ,  A23V2250/161 ,  A23V2250/1642 ,  A23V2250/032 ,  A23V2250/1846 ,  A23V2250/1852 ,  A23V2250/1848 ,  A23V2250/156 ,  A23V2250/5114 ,  A23V2250/704 ,  A23V2250/716

摘要： The present invention relates to a preparation suitable for the prevention and/or treatment of vascular disorders, comprising the following fractions: fraction a) consisting of long chain polyunsaturated fatty acids; fraction b) consisting of phospholipids, which fraction contains at least two different phospholipids selected from the group consisting of phosphatidylserine, phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine. fraction c) consisting of compounds which are a factor in methionine metabolism, which fraction contains at least one member selected from the group consisting of folic acid, vitamin B12, vitamin B6, magnesium and zinc.

摘要翻译： 本发明涉及适用于预防和/或治疗血管疾病的制剂，其包含以下级分：级分a）由长链多不饱和脂肪酸组成; 组分b）由磷脂组成，该级分含有至少两种选自磷脂酰丝氨酸，磷脂酰肌醇，磷脂酰胆碱和磷脂酰乙醇胺的不同磷脂。 组分c）由作为甲硫氨酸代谢因子的化合物组成，该级分含有选自叶酸，维生素B12，维生素B6，镁和锌中的至少一种。

公开(公告)号：US07174791B2

公开(公告)日：2007-02-13

申请号：US11176167

申请日：2005-07-07

申请人： Mark Peter Modera ,  Robert Hageman ,  Brian Farmer

发明人： Mark Peter Modera ,  Robert Hageman ,  Brian Farmer

IPC分类号： G01F1/00

CPC分类号： G01F1/10 ,  G01F1/363

摘要： A fan powered by a controlled external energy source and a flow measurement device measure the airflow exiting or entering grilles/registers of an HVAC system without impeding the airflow being measured. A flow straightening element is preferably employed to overcome any effects of a non-uniform or swirled airflow profile on the fan. Preferably, the RPM of the fan is measured to determine the airflow. The RPM/flow calibration of the fan is insensitive to pressure differentials or the fan is a pressure-sensitive fan submitted to appropriate pressure differentials. Alternatively, the voltage or current supplied to the external energy source is used to determine the airflow. Finally, the pressure differential across the flow straightening element can be measured to determine airflow, eliminating the impact of pressure differential across the flow measurement device and fan.

摘要翻译： 由受控的外部能源供电的风扇和流量测量装置测量出流或进入HVAC系统的格栅/寄存器的气流，而不会阻碍被测量的气流。 优选地采用流动矫正元件来克服风扇上的不均匀或涡流气流分布的任何影响。 优选地，测量风扇的RPM以确定气流。 风扇的RPM /流量校准对压差不敏感，或风扇是经过适当压差的压敏风扇。 或者，使用提供给外部能量源的电压或电流来确定气流。 最后，可以测量整流元件上的压力差，以确定气流，消除流量测量装置和风扇两端的压差的影响。

公开(公告)号：US20070232568A1

公开(公告)日：2007-10-04

申请号：US10572240

申请日：2004-09-20

申请人： Klaske van Norren ,  Eduard van Hoorn ,  Robert Hageman ,  Kelly Lamb

发明人： Klaske van Norren ,  Eduard van Hoorn ,  Robert Hageman ,  Kelly Lamb

IPC分类号： A61K31/70 ,  A23L1/30 ,  A61K31/7004 ,  A61K31/715 ,  A61P11/00 ,  A61K31/7016 ,  A23L1/305

CPC分类号： A61K31/715 ,  A23L33/10 ,  A23L33/115 ,  A23V2002/00 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7016 ,  A61K38/06 ,  A61K2300/00 ,  A23V2250/54246 ,  A23V2250/61 ,  A23V2250/5114 ,  A23V2250/54252 ,  A23V2250/026 ,  A23V2250/606 ,  A23V2250/0634 ,  A23V2250/032 ,  A23V2250/616

摘要： One aspect of the present invention is concerned with a method of treating or preventing pulmonary inflammation as a complication ensuing from physical trauma, bacteraemia or viral inflection, said method comprising enterally administering at least one or more glutathione promoters selected from: −0.3-20 g, preferably 0.5-5 g pyruvate equivalents; −0.1-5 g, preferably 0.2-2 g oxaloacetate equivalents; −0.01-1 g, preferably 0.02-0.5 g lipoic acid equivalents; and at least 20 g of digestible water soluble carbohydrates, in the form of an aqueous liquid composition containing at least 10 g/l of said digestible water soluble carbohydrates. Another aspect of the invention relates to an aqueous liquid composition suitable for enteral administration containing: 2 to 20 wt. % digestible dissolved carbohydrates; two or more glutathione promoters selected from: 0.5 to 50 g/l pyruvate equivalents; 0.05 to 20 g/l oxaloacetate equivalents; 0.05 to 5 g/l cystein equivalents; and at least 45 wt % water.

摘要翻译： 本发明的一个方面涉及一种治疗或预​​防肺部炎症的方法，作为从身体创伤，细菌血症或病毒变形引起的并发症，所述方法包括肠内施用至少一种或多种谷胱甘肽启动子，所述谷胱甘肽启动子选自：-0.3-20g ，优选0.5-5克丙酮酸当量; -0.1-5g，优选0.2-2g草酰乙酸当量; -0.01-1g，优选0.02-0.5g硫辛酸当量; 和含有至少10g / l所述可消化水溶性碳水化合物的含水液体组合物形式的至少20g可消化水溶性碳水化合物。 本发明的另一方面涉及适用于肠内给药的含水液体组合物，其含有：2-20wt。 消化溶解碳水化合物％ 两种或更多种谷胱甘肽启动子，其选自：0.5至50g / l丙酮酸当量; 0.05〜20g / l草酰乙酸当量; 0.05至5g / l半胱氨酸当量; 和至少45重量％的水。

公开(公告)号：US20070190064A1

公开(公告)日：2007-08-16

申请号：US10544642

申请日：2005-02-05

申请人： Gelske Speelmans ,  Adrianus Vriesema ,  Anita Vreugdenhil ,  Willem Buurman ,  Johannes Greve ,  Zandrie Hofman ,  Inge Kivit ,  Robert Hageman

发明人： Gelske Speelmans ,  Adrianus Vriesema ,  Anita Vreugdenhil ,  Willem Buurman ,  Johannes Greve ,  Zandrie Hofman ,  Inge Kivit ,  Robert Hageman

IPC分类号： A61K38/17 ,  A61K39/395

CPC分类号： A61K45/06 ,  A23J7/00 ,  A23L33/115 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/685 ,  A61K35/57 ,  A61K35/60 ,  A61K36/185 ,  A61K36/28 ,  A61K36/286 ,  A61K36/31 ,  A61K36/35 ,  A61K36/48 ,  A61K36/63 ,  A61K36/889 ,  A61K36/899 ,  A23V2250/54246 ,  A23V2250/61 ,  A23V2250/616 ,  A23V2250/5114 ,  A23V2250/1846 ,  A23V2250/1848 ,  A23V2250/194 ,  A23V2250/628

摘要： Enteral compositions and use thereof, which compositions contain proteins and lipids, for the prevention and/or treatment of sepsis; the lipid fraction being particularly rich in phospholipids.

摘要翻译： 肠内成分及其用途，该组合物含有蛋白质和脂质，用于预防和/或治疗败血症; 脂质部分特别富含磷脂。

公开(公告)号：US20050287204A1

公开(公告)日：2005-12-29

申请号：US10518623

申请日：2003-06-19

申请人： Robert Hageman ,  George Verlaan

发明人： Robert Hageman ,  George Verlaan

IPC分类号： A23L1/302 ,  A23L1/305 ,  A61K31/195 ,  A61K38/16 ,  A61K45/06 ,  A61K31/714 ,  A61K31/198 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/525

CPC分类号： A61K45/06 ,  A23L33/15 ,  A23L33/17 ,  A23L33/175 ,  A23L33/19 ,  A61K31/195 ,  A61K38/16 ,  A61K2300/00

摘要： There is provided a nutritional or pharmaceutical composition comprising a protein fraction containing L-serine and an energy metabolism precursor wherein the composition is free of glycine or if glycine is present within the composition, the weight ratio of L-serine: glycine after hydrolysis of the composition is of more than 2.7:1, which composition provides an effective creatine response within mammals muscle and methylation reaction capacity of organisms.

摘要翻译： 提供了包含含有L-丝氨酸的蛋白质级分和能量代谢前体的营养或药物组合物，其中所述组合物不含甘氨酸，或者如果甘氨酸存在于组合物内，L-丝氨酸：甘氨酸在水解后的重量比为 组成超过2.7:1，该组合物在哺乳动物肌肉中提供有效的肌酸反应和生物体的甲基化反应能力。

公开(公告)号：US06923072B2

公开(公告)日：2005-08-02

申请号：US10338447

申请日：2003-01-08

申请人： Mark Peter Modera ,  Robert Hageman ,  Brian Farmer

发明人： Mark Peter Modera ,  Robert Hageman ,  Brian Farmer

IPC分类号： G01F1/10 ,  G01F1/36 ,  G01F1/00

CPC分类号： G01F1/10 ,  G01F1/363

摘要： A fan powered by a controlled external energy source and a flow measurement device measure the airflow exiting or entering grilles/registers of an HVAC system without impeding the airflow being measured. A flow straightening element is preferably employed to overcome any effects of a non-uniform or swirled airflow profile on the fan. Preferably, the RPM of the fan is measured to determine the airflow. The RPM/flow calibration of the fan is insensitive to pressure differentials or the fan is a pressure-sensitive fan submitted to appropriate pressure differentials. Alternatively, the voltage or current supplied to the external energy source is used to determine the airflow. Finally, the pressure differential across the flow straightening element can be measured to determine airflow, eliminating the impact of pressure differential across the flow measurement device and fan.

摘要翻译： 由受控的外部能源供电的风扇和流量测量装置测量出流或进入HVAC系统的格栅/寄存器的气流，而不会阻碍被测量的气流。 优选地采用流动矫正元件来克服风扇上的不均匀或涡流气流分布的任何影响。 优选地，测量风扇的RPM以确定气流。 风扇的RPM /流量校准对压差不敏感，或风扇是经过适当压差的压敏风扇。 或者，使用提供给外部能量源的电压或电流来确定气流。 最后，可以测量整流元件上的压力差，以确定气流，消除流量测量装置和风扇两端的压差的影响。

公开(公告)号：US20050136129A1

公开(公告)日：2005-06-23

申请号：US10993348

申请日：2004-11-22

申请人： Maria Verheul-Koot ,  Chantal Kleijer ,  Robert Hageman ,  Roelof Bork ,  Maud Goethals

发明人： Maria Verheul-Koot ,  Chantal Kleijer ,  Robert Hageman ,  Roelof Bork ,  Maud Goethals

IPC分类号： A23L33/00 ,  A23L33/105 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A61K31/07 ,  A61K31/195 ,  A61K31/198 ,  A61K31/202 ,  A61K31/352 ,  A61K31/353 ,  A61K31/375 ,  A61K33/30 ,  A61K38/00 ,  A61P17/02 ,  A61K31/714 ,  A01N33/12 ,  A61K31/355 ,  A61K31/4188 ,  A61K33/04 ,  A61K33/32

CPC分类号： A61K33/30 ,  A23L33/105 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/01 ,  A61K31/045 ,  A61K31/355 ,  A61K31/375 ,  A61K38/02 ,  A61K45/06 ,  Y10S514/905 ,  A23V2250/708 ,  A23V2250/712 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/71 ,  A23V2250/705 ,  A23V2250/70 ,  A23V2250/1614 ,  A23V2250/1582 ,  A23V2250/16 ,  A23V2250/1578 ,  A23V2250/1618 ,  A23V2250/161 ,  A23V2250/1598 ,  A23V2250/156 ,  A23V2250/0606 ,  A23V2250/0632 ,  A23V2250/06 ,  A23V2250/2116 ,  A23V2250/0612 ,  A23V2250/0644 ,  A23V2250/304 ,  A23V2250/211 ,  A61K2300/00

摘要： The invention pertains to a method of treating or preventing pressure ulcers, comprising enterally administering to a subject in need thereof a composition comprising proteins, carbohydrates, fats, arginine or equivalents thereof, ascorbic acid equivalents and α-tocopherol equivalents, wherein arginine or equivalents thereof is administered in a daily amount of 3-15 g, ascorbic acid equivalents are administered in a daily amount of 180-840 mg and α-tocopherol equivalents are administered in a daily amount of 50-400 mg.

摘要翻译： 本发明涉及治疗或预防压力性溃疡的方法，其包括向有需要的受试者肠内施用包含蛋白质，碳水化合物，脂肪，精氨酸或其等同物，抗坏血酸当量和α-生育酚当量的组合物，其中精氨酸或其等价物 以每日3-15g的量施用，抗坏血酸当量以180-840mg的日剂量施用，α-生育酚当量以每日50-400mg的量施用。

公开(公告)号：US20080032916A1

公开(公告)日：2008-02-07

申请号：US11572197

申请日：2005-07-18

申请人： Robert Hageman

发明人： Robert Hageman

IPC分类号： A61K38/02 ,  A61K38/16

CPC分类号： A61K31/714 ,  A23L13/424 ,  A23L13/65 ,  A23L23/10 ,  A23L33/17 ,  A23L33/175 ,  A23L33/18 ,  A23L33/185 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/198 ,  A61K31/4188 ,  A61K36/48 ,  A61K36/81 ,  A61K36/899 ,  A61K38/01 ,  A61K38/02 ,  A61K2300/00 ,  A23V2200/328 ,  A23V2250/0636 ,  A23V2250/061 ,  A23V2250/0628 ,  A23V2250/062 ,  A23V2250/5114 ,  A23V2250/608 ,  A23V2250/61 ,  A23V2250/1882 ,  A23V2250/5106 ,  A23V2250/156 ,  A23V2250/15 ,  A23V2200/332 ,  A23V2250/0618 ,  A23V2250/54252 ,  A23V2250/5488 ,  A23V2250/612 ,  A23V2250/1842 ,  A23V2250/702 ,  A23V2250/712 ,  A23V2250/7042 ,  A23V2250/7052 ,  A23V2250/72 ,  A23V2250/7046 ,  A23V2250/0644 ,  A23V2250/1614 ,  A23V2250/1618 ,  A23V2250/1582 ,  A23V2250/1592 ,  A23V2250/1588

摘要： The invention relates to the use of specific protein and/or peptide fractions having a high aspartate content for regulating plasma glucose concentrations and increasing insulin sensitivity in a mammal. It has been found that high amounts of aspartate equivalents, especially in relative absence of glutamate equivalents, increase the glucose uptake of peripheral cells and improve the reaction of the liver on dietetic glucose consumption. As a result it has a favourable effect on the blood glucose levels of a person suffering from hyperglycaemia, in particular postprandial and post-surgery hyperglycaemia and/or insulin resistance. The invention relates to a complete food fortified with aspartate equivalents as well as a supplement rich in aspartate equivalents that is given simultaneously with or even minutes up to an hour prior to the consumption of a meal comprising glucose. The nutritional or pharmaceutical composition contains at least one protein having a high aspartate content, preferably of soy or dairy origin, which is further enriched with aspartate equivalents from another protein and/or free aspartate equivalents. The protein fraction comprises glutamate equivalents in a weight ratio of aspartate equivalents to glutamate equivalents (asp:glu) between 0.41:1 and 5:1.

摘要翻译： 本发明涉及具有高天冬氨酸含量的特定蛋白质和/或肽级分用于调节哺乳动物血浆葡萄糖浓度和增加胰岛素敏感性的用途。 已经发现，大量天冬氨酸当量，特别是相对不存在谷氨酸当量时，增加外周细胞的葡萄糖摄取并改善肝脏对饮食葡萄糖消耗的反应。 因此，它对患有高血糖，特别是餐后和手术后高血糖症和/或胰岛素抵抗的人的血糖水平具有有利的影响。 本发明涉及用天冬氨酸当量加强的完整食物以及富含天冬氨酸当量的补充剂，其在消耗包含葡萄糖的膳食之前同时或甚至数分钟至少一小时。 营养或药物组合物含有至少一种具有高天冬氨酸含量，优选大豆或乳制品来源的蛋白质，其进一步富含来自另一蛋白质和/或游离天冬氨酸当量的天冬氨酸当量。 蛋白质级分包含谷氨酸当量，天门冬氨酸当量与谷氨酸当量（asp：glu）的重量比在0.41:1和5:1之间。

公开(公告)号：US20070225203A1

公开(公告)日：2007-09-27

申请号：US10572239

申请日：2004-09-20

申请人： Klaske Van Norren ,  Eduard Van Hoorn ,  Robert Hageman ,  Houkje Bouritius ,  Adrianus Vriesema ,  Cornelus Van Limpt ,  Mirian Lansink ,  Marieke Van Meeteren

发明人： Klaske Van Norren ,  Eduard Van Hoorn ,  Robert Hageman ,  Houkje Bouritius ,  Adrianus Vriesema ,  Cornelus Van Limpt ,  Mirian Lansink ,  Marieke Van Meeteren

IPC分类号： A61K38/55 ,  A61K31/70 ,  A61K31/715 ,  A61K31/718 ,  A61K31/724 ,  A61K31/7076 ,  A61K31/525

CPC分类号： A23L33/18 ,  A23L33/00 ,  A23L33/13 ,  A23V2002/00 ,  A23V2250/7056 ,  A23V2250/61 ,  A23V2250/5114 ,  A23V2250/54246 ,  A23V2250/616 ,  A23V2250/626 ,  A23V2250/5488

摘要： One aspect of the present invention relates to a method of preventing multiple organ dysfunction syndrome in a mammal suffering from trauma, said method comprising enterally administering to said mammal, within 24 hours of the occurrence of the trauma, (i) digestible water soluble carbohydrates and (ii) a liver guanosine-5′-triphosphate (GTP) increasing component and/or peptides with Angiotensin Converting Enzyme (ACE) inhibiting activity. Another aspect of the invention relates to an aqueous liquid composition containing: −20-200 g/l digestible dissolved carbohydrates; −5-5000 mg/l guanosine equivalents in combination with 1-100 g/l ribose equivalents and/or 2-2000 mg/l flavonoides; or 0.01 to 10 mM of peptides with ACE inhibiting activity; and −45 to 97.95 wt. % water.

摘要翻译： 本发明的一个方面涉及一种在患有创伤的哺乳动物中预防多器官功能障碍综合征的方法，所述方法包括在创伤发生后24小时内对所述哺乳动物进行肠内施用，（i）可消化的水溶性碳水化合物和 （ii）肝素鸟苷-5'-三磷酸（GTP）增加组分和/或具有血管紧张素转换酶（ACE）抑制活性的肽。 本发明的另一方面涉及一种水性液体组合物，其含有：-20-200g / l可消化溶解的碳水化合物; -5-5000mg / l鸟苷当量与1-100g / l核糖当量和/或2-2000mg / l黄酮类药物组合; 或0.01至10mM具有ACE抑制活性的肽; 和-45至97.95wt。 ％ 水。

公开(公告)号：US20060084361A1

公开(公告)日：2006-04-20

申请号：US10963767

申请日：2004-10-14

申请人： Anthony Favorito ,  Robert Hageman ,  Matthew Szymanski

发明人： Anthony Favorito ,  Robert Hageman ,  Matthew Szymanski

IPC分类号： A63H3/52 ,  E01B23/00

CPC分类号： A63H18/02 ,  A63H19/30 ,  A63H19/34 ,  A63H19/36

摘要： An accessory device for use with at least one toy vehicle is provided, wherein the accessory device includes a first housing and a second housing. The first housing includes a first passageway configured to permit the toy vehicle to pass entirely through the first housing. The first housing may further include a second passageway configured to permit the toy vehicle to completely pass through the first housing. A sensor may be positioned along the first passageway, the second passageway, or both. The sensor may be configured to detect the passage of the toy vehicle through the passageway and activate a sensory output generating device. The accessory device further includes a second housing attachable to the first housing and includes a passageway configured to permit the toy vehicle to pass entirely through the second housing.

摘要翻译： 提供了一种用于与至少一个玩具车一起使用的附件装置，其中所述附件装置包括第一壳体和第二壳体。 第一壳体包括构造成允许玩具车辆完全穿过第一壳体的第一通道。 第一壳体可以进一步包括构造成允许玩具车辆完全通过第一壳体的第二通道。 传感器可以沿着第一通道，第二通道或两者定位。 传感器可以被配置为检测玩具车辆通过通道的通道并激活感觉输出产生装置。 附件装置还包括可附接到第一壳体的第二壳体，并且包括构造成允许玩具车辆完全穿过第二壳体的通道。