发明申请
US20070232593A1 ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES
有权
反式4取代的5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并咪唑
![ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES](/docs/US/2007-10-04/US20070232593A1/abs.jpg.600x600.jpg)
- 专利标题： ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES
- 专利标题（中）： 反式4取代的5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并咪唑
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申请号： US11680700申请日： 2007-03-01
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公开(公告)号： US20070232593A1公开(公告)日： 2007-10-04
- 发明人: Terence Gilkerson , Roger Nash , Jozef Van Gestel , Lieven Meerpoel
- 申请人： Terence Gilkerson , Roger Nash , Jozef Van Gestel , Lieven Meerpoel
- 优先权： EP00203726.5 20001023
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D487/12
![ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES](/abs-image/US/2007/10/04/US20070232593A1/abs.jpg.150x150.jpg)
摘要：
The present invention concerns compounds for use as a medicine having the formula the N-oxide forms, the salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 represents hydrogen, C1-6alkyl, C1-4alkylthio, C1-4alkyloxy, or halo; R2 represents hydrogen or C1-6alkyl; R3 represents phenyl substituted with halo, cyano, C1-4alkyloxy, C1-4alkylthio, C1-6alkyl, haloC1-6alkyl; 2-thienyl; or 3-thienyl, R4 represents hydrogen; or R2 and R4 form an extra bond, which are active against dermatophytes, and their preparation; it further relates to compositions comprising them, as well as their use as a medicine.
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