公开(公告)号：US20070232593A1

公开(公告)日：2007-10-04

申请号：US11680700

申请日：2007-03-01

申请人： Terence Gilkerson ,  Roger Nash ,  Jozef Van Gestel ,  Lieven Meerpoel

发明人： Terence Gilkerson ,  Roger Nash ,  Jozef Van Gestel ,  Lieven Meerpoel

IPC分类号： A61K31/55 ,  C07D487/12

CPC分类号： C07D487/04 ,  A61K31/55 ,  A61K31/551

摘要： The present invention concerns compounds for use as a medicine having the formula the N-oxide forms, the salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 represents hydrogen, C1-6alkyl, C1-4alkylthio, C1-4alkyloxy, or halo; R2 represents hydrogen or C1-6alkyl; R3 represents phenyl substituted with halo, cyano, C1-4alkyloxy, C1-4alkylthio, C1-6alkyl, haloC1-6alkyl; 2-thienyl; or 3-thienyl, R4 represents hydrogen; or R2 and R4 form an extra bond, which are active against dermatophytes, and their preparation; it further relates to compositions comprising them, as well as their use as a medicine.

摘要翻译： 本发明涉及用作具有N-氧化物形式的药物的化合物，其盐，季胺和立体化学异构形式，其中R 1表示氢，C 1〜 C 1 -C 6烷基，C 1-4烷基硫基，C 1-4烷基氧基或卤素; R 2表示氢或C 1-6烷基; R 3表示被卤素，氰基，C 1-4烷氧基，C 1-4烷基硫基，C 1-6烷基取代的苯基 烷基，卤代C 1-6烷基; 2-噻吩基; 或3-噻吩基，R 4表示氢; 或R 2和R 4形成对皮肤癣菌有活性的额外的结合，及其制备; 它还涉及包含它们的组合物以及它们作为药物的用途。