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发明申请
US20070269863A1 Process for the production of preformed conjugates of albumin and a therapeutic agent 审中-公开
用于生产白蛋白和治疗剂的预制缀合物的方法

Process for the production of preformed conjugates of albumin and a therapeutic agent
摘要：
The present invention provides processes for the production of preformed albumin conjugates. In particular, the invention provides processes for the in-vitro conjugation of a therapeutic compound to recombinant albumin, wherein a therapeutic compound comprising a reactive group is contacted to recombinant albumin in solution to form a conjugate. The processes provide for conjugation to albumin species of increasing homogeneity. The resulting conjugate is purified by chromatography, in particular hydrophobic interaction chromatography comprising phenyl sepharose and butyl sepharose chromatography.
摘要（中）：

本发明提供了生产预制白蛋白缀合物的方法。 特别地，本发明提供了治疗化合物与重组白蛋白体外共轭的方法，其中包含反应性基团的治疗化合物在溶液中与重组白蛋白接触以形成缀合物。 该方法提供了与增加同质性的白蛋白物质的缀合。 所得的缀合物通过色谱纯化，特别是包括苯基琼脂糖和丁基琼脂糖凝胶层析的疏水相互作用层析。

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