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    Compounds For Specific Viral Target
    1.
    发明申请
    Compounds For Specific Viral Target 审中-公开
    特定病毒靶标化合物

    公开(公告)号：US20080039532A1

    公开(公告)日：2008-02-14

    申请号：US11579929

    申请日：2005-05-06

    申请人： Dominique Bridon ,  Nathalie Bousquet-Gagnon ,  Xicai Huang ,  Omar Quraishi

    发明人： Dominique Bridon ,  Nathalie Bousquet-Gagnon ,  Xicai Huang ,  Omar Quraishi

    IPC分类号： A61K47/48 ,  A61K47/42 ,  C07K14/00

    CPC分类号： C07K14/005 ,  A61K47/542 ,  C12N2740/16122

    摘要： The present application relates to a compound having a formula 1: B—R1-R2-M wherein B is a binding element for recognizing and binding a target; R1 is a first group of atoms for reacting with a functionality of the target so as to form a covalent bond with the target; R2 is a second group of atoms; R1 and R2 being such that the formation of the covalent bond between R1 and the target generates cleavage of the bond between R1 and R2 so as to free R2-M; and M is selected from the group consisting of a hydrogen atom and a pharmaceutically acceptable moiety. Alternatively, R1 and R2 can be inverted to form the formula II: B—R2-R1-M and being such that the formation of the covalent bond between R1 and the target generates cleavage of the bond between R1 and R2 so as to free R2-B.

    摘要翻译： 本申请涉及具有式1的化合物：B-R1-R2-M其中B是用于识别和结合靶的结合元件; R1是与靶的功能性反应的第一组原子，以与靶形成共价键; R2是第二组原子; R1和R2使得R1和靶之间的共价键的形成产生R1和R2之间的键的切割，以游离R2-M; 并且M选自氢原子和药学上可接受的部分。 或者，可以将R1和R2反转以形成式II：B-R2-R1-M，并且使得R1和靶之间的共价键的形成产生R1和R2之间的键的切割，以释放R2 -B。

    THOMBOPOIETIN PEPTIDE CONJUGATES
    4.
    发明申请
    THOMBOPOIETIN PEPTIDE CONJUGATES 审中-公开
    THOMBOPOIETIN胶原蛋白

    公开(公告)号：US20090054332A1

    公开(公告)日：2009-02-26

    申请号：US12143780

    申请日：2008-06-21

    申请人： Jean-Philippe Estradier ,  Martin Robitaille ,  Karen Thibaudeau ,  Dominique P. Bridon ,  Xicai Huang ,  Omar Quraishi ,  Nathalie Bousquet-Gagnon

    发明人： Jean-Philippe Estradier ,  Martin Robitaille ,  Karen Thibaudeau ,  Dominique P. Bridon ,  Xicai Huang ,  Omar Quraishi ,  Nathalie Bousquet-Gagnon

    IPC分类号： A61K38/16 ,  C07K7/06 ,  C07K7/08 ,  C07K1/14 ,  C07K14/76 ,  C07K19/00

    CPC分类号： A61K47/644 ,  A61K47/60 ,  A61K47/643 ,  A61K47/65

    摘要： The present invention relates to compounds comprising modified thrombopoietin peptides and conjugates of such modified peptides to serum components, typically serum proteins or peptides. The compounds and conjugates of the invention comprise a reactive group or a residue of a reactive group, which is covalently attached to a modified peptide, optionally through a linking group. The present invention also provides methods for the covalent attachment of a modified peptide to a serum protein or peptide to form a conjugate of the invention. The conjugates of the invention typically exhibit a longer in vivo circulating half-life compared to the corresponding unconjugated peptides. The conjugates of the invention also retain at least some of the biological activity of the unconjugated peptides, and typically exhibit increased biological activity compared to the unconjugated peptides. The present invention also provides methods for the treatment and prevention of a disease or disorder comprising the administration of one or more of the compounds or conjugates of the invention to a subject in need of such treatment or prevention.

    摘要翻译： 本发明涉及包含修饰的血小板生成素肽和这种修饰肽与血清成分（通常为血清蛋白或肽）的缀合物的化合物。 本发明的化合物和缀合物包含反应性基团或反应性基团的残基，其可任选地通过连接基团与修饰的肽共价连接。 本发明还提供了将修饰的肽共价连接到血清蛋白或肽以形成本发明的缀合物的方法。 与相应的未结合的肽相比，本发明的缀合物通常表现出较长的体内循环半衰期。 本发明的缀合物还保留非共轭肽的至少一些生物活性，并且与非共轭多肽相比通常表现出增加的生物学活性。 本发明还提供了治疗和预防疾病或病症的方法，包括将本发明的一种或多种化合物或缀合物施用于需要这种治疗或预​​防的受试者。

    LONG LASTING INHIBITORS OF VIRAL INFECTION
    8.
    发明申请
    LONG LASTING INHIBITORS OF VIRAL INFECTION 审中-公开
    长期感染的长激素抑制剂

    公开(公告)号：US20090088378A1

    公开(公告)日：2009-04-02

    申请号：US12122643

    申请日：2008-05-16

    申请人： Omar Quraishi ,  Cheryl A. Stoddart ,  Paul L. Black

    发明人： Omar Quraishi ,  Cheryl A. Stoddart ,  Paul L. Black

    IPC分类号： A61K38/16 ,  A61K38/38 ,  A61P31/12

    CPC分类号： C07K14/76 ,  C07K2319/31

    摘要： This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory synctial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.

    摘要翻译： 本发明涉及作为病毒感染抑制剂和/或表现出抗融合性质的C34肽衍生物。 特别地，本发明涉及具有长期持续时间的针对人类免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））的抑制活性的C34衍生物 的治疗各自病毒感染的作用。

    CYSTEIC ACID DERIVATIVES OF ANTI-VIRAL PEPTIDES
    9.
    发明申请
    CYSTEIC ACID DERIVATIVES OF ANTI-VIRAL PEPTIDES 审中-公开
    抗病毒肽的氨基酸衍生物

    公开(公告)号：US20090088377A1

    公开(公告)日：2009-04-02

    申请号：US12122627

    申请日：2008-05-16

    申请人： Omar Quraishi ,  Martin Robitaille ,  Dominique P. Bridon

    发明人： Omar Quraishi ,  Martin Robitaille ,  Dominique P. Bridon

    IPC分类号： A61K38/16 ,  C07K14/00 ,  C07K14/76

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2740/16122 ,  Y02A50/463

    摘要： This invention relates to C34 peptide derivatives having improved aqueous solubility that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory synctial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.

    摘要翻译： 本发明涉及具有改善的水溶性的C34肽衍生物，其是病毒感染的抑制剂和/或表现出抗融合性质。 特别地，本发明涉及具有长期持续时间的针对人类免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））的抑制活性的C34衍生物 的治疗各自病毒感染的作用。