发明申请
- 专利标题: Novel pyridine Derivative and Pyrimidine Derivative (1)
- 专利标题(中): 新型吡啶衍生物和嘧啶衍生物(1)
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申请号: US10577065申请日: 2005-02-25
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公开(公告)号: US20070270421A1公开(公告)日: 2007-11-22
- 发明人: Tomohiro Matsushima , Keiko Takahashi , Setsuo Funasaka , Hiroshi Obaishi
- 申请人: Tomohiro Matsushima , Keiko Takahashi , Setsuo Funasaka , Hiroshi Obaishi
- 优先权: JP2004-054451 20040227; JP2004-370801 20041222
- 国际申请: PCT/JP05/03701 WO 20050225
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; A61K31/445 ; A61K31/497 ; A61K31/505 ; A61K31/535 ; A61P35/04 ; C07D211/68 ; C07D239/02 ; C07D239/42 ; C07D413/02
摘要:
A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R1 represents C1-6 alkyl or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents C1-6 alkyl or the like; V1 represents oxygen or the like; V2 represents oxygen or sulfur; W represents —NH— or the like; X represents —CH═, nitrogen or the like; and Y represents oxygen or the like.]
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