Invention Application
- Patent Title: Raf Modulators and Methods of Use
- Patent Title (中): Raf调制器和使用方法
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Application No.: US11568789Application Date: 2005-03-25
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Publication No.: US20080009488A1Publication Date: 2008-01-10
- Inventor: Neel Anand , Charles Blazey , Owen Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Curtis , Larisa Dubenko , Abigail Kennedy , Steven Defina , Angie Kim , Jean-Claire Manalo , Csaba Peto , Kenneth Rice , Tsze Tsang , Anagha Joshi
- Applicant: Neel Anand , Charles Blazey , Owen Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Curtis , Larisa Dubenko , Abigail Kennedy , Steven Defina , Angie Kim , Jean-Claire Manalo , Csaba Peto , Kenneth Rice , Tsze Tsang , Anagha Joshi
- Applicant Address: US CA San Francisco 94083-0511
- Assignee: EXELIXIS, INC.
- Current Assignee: EXELIXIS, INC.
- Current Assignee Address: US CA San Francisco 94083-0511
- International Application: PCT/US05/10187 WO 20050325
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; A61K31/454 ; A61K31/497 ; A61K31/538 ; A61P35/00 ; C07D211/32 ; C07D235/04 ; C07D265/36 ; C07D403/14 ; C12N5/06 ; C12N5/08 ; G01N33/573
Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
Public/Granted literature
- US07846959B2 Raf modulators and methods of use Public/Granted day:2010-12-07
Information query
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