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公开(公告)号:US20080009488A1
公开(公告)日:2008-01-10
申请号:US11568789
申请日:2005-03-25
申请人: Neel Anand , Charles Blazey , Owen Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Curtis , Larisa Dubenko , Abigail Kennedy , Steven Defina , Angie Kim , Jean-Claire Manalo , Csaba Peto , Kenneth Rice , Tsze Tsang , Anagha Joshi
发明人: Neel Anand , Charles Blazey , Owen Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Curtis , Larisa Dubenko , Abigail Kennedy , Steven Defina , Angie Kim , Jean-Claire Manalo , Csaba Peto , Kenneth Rice , Tsze Tsang , Anagha Joshi
IPC分类号: A61K31/4184 , A61K31/454 , A61K31/497 , A61K31/538 , A61P35/00 , C07D211/32 , C07D235/04 , C07D265/36 , C07D403/14 , C12N5/06 , C12N5/08 , G01N33/573
CPC分类号: C07D413/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译: 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖,分化,程序性细胞死亡,迁移和化学侵蚀的化合物。 本发明的化合物抑制,调节和/或调节激酶,特别是Raf。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。
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公开(公告)号:US20070032515A1
公开(公告)日:2007-02-08
申请号:US10565657
申请日:2004-07-23
申请人: Neel Anand , Charles Blazey , Owen Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Curtis , Larisa Dubenko , Abigail Kennedy , Richard Khoury , Angie Kim , Jean-Claire Manalo , Csaba Peto , Kenneth Rice , Tsze Tsang
发明人: Neel Anand , Charles Blazey , Owen Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Curtis , Larisa Dubenko , Abigail Kennedy , Richard Khoury , Angie Kim , Jean-Claire Manalo , Csaba Peto , Kenneth Rice , Tsze Tsang
IPC分类号: A61K31/4745 , C07D471/02
CPC分类号: C07D471/04 , C07D491/147 , C07D519/00
摘要: The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.
摘要翻译: 本发明包括包含作为ALK抑制剂的化合物的化合物和药物组合物。 本发明还包括使用化合物和组合物来治疗由ALK介导的疾病,包括诸如癌症,免疫学障碍,心血管疾病和其它退行性疾病的疾病的方法。
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