公开(公告)号：US20080009488A1

公开(公告)日：2008-01-10

申请号：US11568789

申请日：2005-03-25

Applicant: Neel Anand ,  Charles Blazey ,  Owen Bowles ,  Joerg Bussenius ,  Simona Costanzo ,  Jeffry Curtis ,  Larisa Dubenko ,  Abigail Kennedy ,  Steven Defina ,  Angie Kim ,  Jean-Claire Manalo ,  Csaba Peto ,  Kenneth Rice ,  Tsze Tsang ,  Anagha Joshi

Inventor： Neel Anand ,  Charles Blazey ,  Owen Bowles ,  Joerg Bussenius ,  Simona Costanzo ,  Jeffry Curtis ,  Larisa Dubenko ,  Abigail Kennedy ,  Steven Defina ,  Angie Kim ,  Jean-Claire Manalo ,  Csaba Peto ,  Kenneth Rice ,  Tsze Tsang ,  Anagha Joshi

IPC: A61K31/4184 ,  A61K31/454 ,  A61K31/497 ,  A61K31/538 ,  A61P35/00 ,  C07D211/32 ,  C07D235/04 ,  C07D265/36 ,  C07D403/14 ,  C12N5/06 ,  C12N5/08 ,  G01N33/573

CPC classification number: C07D413/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract translation: 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Raf。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。

公开(公告)号：US20060211709A1

公开(公告)日：2006-09-21

申请号：US10513081

申请日：2003-05-02

Applicant: Chris Buhr ,  Tae-Gon Baik ,  Sunghoon Ma ,  Zerom Tesfai ,  Longcheng Wang ,  Erick Co ,  Sergey Epshteyn ,  Abigail Kennedy ,  Baili Chen ,  Larisa Dubenko ,  Neel Anand ,  Tsze Tsang ,  John Nuss ,  Csabaj Peto ,  Kenneth Rice ,  Mohamed Ibrahim ,  Xian Shi ,  James Leahy ,  Jeff Chen ,  Lisa Dalrymple ,  Timothy Forsyth ,  Tai Huynh ,  Grace Mann ,  Larry Mann ,  Craig Takeuchi

Inventor： Chris Buhr ,  Tae-Gon Baik ,  Sunghoon Ma ,  Zerom Tesfai ,  Longcheng Wang ,  Erick Co ,  Sergey Epshteyn ,  Abigail Kennedy ,  Baili Chen ,  Larisa Dubenko ,  Neel Anand ,  Tsze Tsang ,  John Nuss ,  Csabaj Peto ,  Kenneth Rice ,  Mohamed Ibrahim ,  Xian Shi ,  James Leahy ,  Jeff Chen ,  Lisa Dalrymple ,  Timothy Forsyth ,  Tai Huynh ,  Grace Mann ,  Larry Mann ,  Craig Takeuchi

IPC: A61K31/497 ,  C07D403/02

CPC classification number: C07D241/26 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12

Abstract: Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.

Abstract translation: 公开了取代的芳基1,4-吡嗪衍生物及其在治疗焦虑症，抑郁症和应激相关疾病中的用途。

公开(公告)号：US20100228292A1

公开(公告)日：2010-09-09

申请号：US12309722

申请日：2007-07-24

Applicant: Benjamin Arnold ,  Neel Anand ,  William Taylor ,  Rich Mueller ,  Eric Dasso ,  G. Bryan Cornwall ,  Matthew Copp

Inventor： Benjamin Arnold ,  Neel Anand ,  William Taylor ,  Rich Mueller ,  Eric Dasso ,  G. Bryan Cornwall ,  Matthew Copp

IPC: A61B17/70

CPC classification number: A61B17/7005 ,  A61B17/7008 ,  A61B17/7031 ,  A61B17/7037

Abstract: A dynamic stabilization system including a dynamic rod with a first and second coupler assemblies, a pre-tensioned central cord and a flexible bumper, which are coupled to the bony structures of the spine by way of pedicle screws for use in spinal fixation surgery.

Abstract translation: 动态稳定系统包括具有第一和第二联接器组件的动态杆，预张紧的中心绳索和柔性保险杠，其通过用于脊柱固定手术的椎弓根螺钉联接到脊柱的骨结构。

公开(公告)号：US20070032515A1

公开(公告)日：2007-02-08

申请号：US10565657

申请日：2004-07-23

Applicant: Neel Anand ,  Charles Blazey ,  Owen Bowles ,  Joerg Bussenius ,  Simona Costanzo ,  Jeffry Curtis ,  Larisa Dubenko ,  Abigail Kennedy ,  Richard Khoury ,  Angie Kim ,  Jean-Claire Manalo ,  Csaba Peto ,  Kenneth Rice ,  Tsze Tsang

Inventor： Neel Anand ,  Charles Blazey ,  Owen Bowles ,  Joerg Bussenius ,  Simona Costanzo ,  Jeffry Curtis ,  Larisa Dubenko ,  Abigail Kennedy ,  Richard Khoury ,  Angie Kim ,  Jean-Claire Manalo ,  Csaba Peto ,  Kenneth Rice ,  Tsze Tsang

IPC: A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04 ,  C07D491/147 ,  C07D519/00

Abstract: The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.

Abstract translation: 本发明包括包含作为ALK抑制剂的化合物的化合物和药物组合物。 本发明还包括使用化合物和组合物来治疗由ALK介导的疾病，包括诸如癌症，免疫学障碍，心血管疾病和其它退行性疾病的疾病的方法。

公开(公告)号：US20060069077A1

公开(公告)日：2006-03-30

申请号：US10522004

申请日：2003-07-14

Applicant: Kenneth Rice ,  Neel Anand ,  Joerg Bussenius ,  Simona Costanzo ,  Abigail Kennedy ,  Angie Kim ,  Csaba Peto ,  Tsze Tsang ,  Charles Blazey

Inventor： Kenneth Rice ,  Neel Anand ,  Joerg Bussenius ,  Simona Costanzo ,  Abigail Kennedy ,  Angie Kim ,  Csaba Peto ,  Tsze Tsang ,  Charles Blazey

IPC: A61K31/517 ,  C07D239/94 ,  C07D239/88

CPC classification number: C07D403/12 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/7064 ,  C07D239/94 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D451/06 ,  C07D471/04 ,  C07D487/04 ,  C07D493/04

Abstract: The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include “spectrum selective” kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR.