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发明申请
US20080039442A1 Compounds With Kv4 Ion Channel Activity 审中-公开
具有Kv4离子通道活性的化合物

Compounds With Kv4 Ion Channel Activity
摘要：
The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula (I), (II), (III) or (IV), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, Formula (I), (II), (III), (IV), wherein X1, X2, Y, Z, W, R1, R8, R9, R10, L, A, z, and n have the meaning defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.
摘要（中）：

本发明涉及与离子通道相互作用的化合物。 特别地，本发明涉及具有结构式（I），（II），（III）或（IV），其立体异构体，互变异构体，外消旋学，前药，代谢物或其药学上可接受的盐和/或溶剂合物的化合物， 式（I），（II），（III），（IV）其中X 1，X 2，Y，Z，W，R 1， R 8，R 9，R 10，L，A，Z和n具有权利要求1中所定义的含义。 本发明还涉及制备所述化合物的方法，包含所述化合物的药物组合物以及所述化合物在治疗人和动物体的方法中的用途。

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