发明申请
- 专利标题： Compounds
- 专利标题（中）： 化合物
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申请号： US11821565申请日： 2007-06-21
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公开(公告)号： US20080039450A1公开(公告)日： 2008-02-14
- 发明人: Annika Jensen , Rune Ringom , Carmen Medina , John Vock , Marie Wiik , Tobias Koolmeister , Johan Angbrant , Martin Henriksson , Teresa Sandvall , Lori Sutin , Lars Johannson , Bjorn Nilsson
- 申请人： Annika Jensen , Rune Ringom , Carmen Medina , John Vock , Marie Wiik , Tobias Koolmeister , Johan Angbrant , Martin Henriksson , Teresa Sandvall , Lori Sutin , Lars Johannson , Bjorn Nilsson
- 优先权： SE0601379-1 20060622
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/4439 ; A61K31/496 ; A61P25/00 ; A61P3/00 ; A61P9/00 ; C07D401/04 ; C07D403/10 ; C07D405/04 ; C07D417/12 ; C07D413/14 ; C07D413/10 ; C07D405/12 ; C07D403/12 ; C07D401/14 ; C07D241/20 ; A61P35/00 ; A61P29/00 ; A61K31/541 ; A61K31/4965
摘要：
The present invention relates to compounds of the general formula I wherein X, Y, Z, A, Ar, R1, R2, R3, and R4 are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.