发明申请
- 专利标题: PROCESS FOR PREPARING BREVIFOLIOL
- 专利标题(中): 制备BREVIFOLIOL的方法
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申请号: US11548166申请日: 2006-10-10
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公开(公告)号: US20080039641A1公开(公告)日: 2008-02-14
- 发明人: Sunil Chattopadhyay , Sachin Srivastava , Arvind Negi , Ranganathan Tirupadiripuliyur , Ankur Garg , Suman Khanuja
- 申请人: Sunil Chattopadhyay , Sachin Srivastava , Arvind Negi , Ranganathan Tirupadiripuliyur , Ankur Garg , Suman Khanuja
- 申请人地址: IN New Delhi
- 专利权人: Council of Scientific and Industrial Research
- 当前专利权人: Council of Scientific and Industrial Research
- 当前专利权人地址: IN New Delhi
- 主分类号: C07D305/00
- IPC分类号: C07D305/00
摘要:
The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genus Taxus by first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40° C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50° C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.
公开/授权文献
- US07579491B2 Process for preparing brevifoliol 公开/授权日:2009-08-25