公开(公告)号：US20080039641A1

公开(公告)日：2008-02-14

申请号：US11548166

申请日：2006-10-10

Applicant: Sunil Chattopadhyay ,  Sachin Srivastava ,  Arvind Negi ,  Ranganathan Tirupadiripuliyur ,  Ankur Garg ,  Suman Khanuja

Inventor： Sunil Chattopadhyay ,  Sachin Srivastava ,  Arvind Negi ,  Ranganathan Tirupadiripuliyur ,  Ankur Garg ,  Suman Khanuja

IPC: C07D305/00

CPC classification number: C07C67/56 ,  C07C2603/30 ,  C07C69/78

Abstract: The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genus Taxus by first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40° C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50° C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.

Abstract translation: 本发明提供了一种通过首先用醇优选在20-40℃的温度下提取植物的干燥和粉碎的叶来生产属于紫杉属的植物的式I的抗癌紫杉烷类短纤维醇的方法 C.然后。 浓缩溶剂以获得醇提取物。 然后将所得醇提物用吸附剂吸附，然后将所得吸附材料在20-50℃的温度范围内干燥4-48小时。 然后将干燥的吸附材料用脂肪族溶剂和氯化溶剂的组合连续萃取并浓缩，得到残余物。 使用柱色谱法如硅胶，佛罗里达和硅酸对残余物进行粗分馏，然后用合适的吸附剂进行色谱以得到短纤维醇。

公开(公告)号：US20070258989A1

公开(公告)日：2007-11-08

申请号：US11634748

申请日：2006-12-05

Applicant: Suman Khanuja ,  Anirban Pal ,  Sunil Chattopadhyay ,  Mahendra Darokar ,  Rajendra Patel ,  Anil Gupta ,  Arvind Negi ,  Tanpreet Kaur ,  Sudeep Tandon ,  Atul Kahol ,  Ankur Garg

Inventor： Suman Khanuja ,  Anirban Pal ,  Sunil Chattopadhyay ,  Mahendra Darokar ,  Rajendra Patel ,  Anil Gupta ,  Arvind Negi ,  Tanpreet Kaur ,  Sudeep Tandon ,  Atul Kahol ,  Ankur Garg

IPC: A61K39/00 ,  A61K36/31 ,  A61P43/00

CPC classification number: A61K31/37 ,  A61K2300/00

Abstract: The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscose along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.

Abstract translation: 本发明提供了一种新型药物组合物，其由从植物Cleome粘胶的种子中分离出的三种分子式1,2和3的香豆素类结合物以及可用作免疫调节剂的药学上可接受的载体组合。 本发明还描述了化合物调节幽门和细胞介导的免疫应答的能力。 它进一步提供了以优化的比例制备所述三种香豆素类黄酮的新型药物组合物以调节幽门和细胞介导的免疫应答的方法。

公开(公告)号：US20060052463A1

公开(公告)日：2006-03-09

申请号：US10937096

申请日：2004-09-08

Applicant: Arvind Negi ,  Sunil Chattopadhyay ,  Sachin Srivastava ,  Asish Bhattacharya

Inventor： Arvind Negi ,  Sunil Chattopadhyay ,  Sachin Srivastava ,  Asish Bhattacharya

IPC: C07D491/14 ,  C07C27/06 ,  C07C65/21 ,  C07C69/76

CPC classification number: C07D459/00 ,  C07C67/31 ,  C07C69/92

Abstract: Demethylation of 3′,4′-dimethoxy or 3′,4′,5′-trimethoxy benzoic ester of a phenol is carried out in the presence of an excess of aluminum halide in an organic solvent to get 4′-Hydroxy, 3′-methoxy or 4′ hydroxy, 3′,5′-dimethoxy benzoic acid ester of a phenol. The reaction is also applicable to 3′,4′,5′-trimethoxy diaryl ketone and some natural products like reserpine.

Abstract translation: 苯酚3'，4'-二甲氧基或3'，4'，5'-三甲氧基苯甲酸酯的脱甲基化在过量的卤化铝在有机溶剂中的存在下进行，得到4'-羟基，3' - 甲氧基或4'羟基，3'，5'-二甲氧基苯甲酸酯。 该反应也适用于3'，4'，5'-三甲氧基二芳基酮和一些天然产物如利血平。