公开(公告)号：US20080039641A1

公开(公告)日：2008-02-14

申请号：US11548166

申请日：2006-10-10

申请人： Sunil Chattopadhyay ,  Sachin Srivastava ,  Arvind Negi ,  Ranganathan Tirupadiripuliyur ,  Ankur Garg ,  Suman Khanuja

发明人： Sunil Chattopadhyay ,  Sachin Srivastava ,  Arvind Negi ,  Ranganathan Tirupadiripuliyur ,  Ankur Garg ,  Suman Khanuja

IPC分类号： C07D305/00

CPC分类号： C07C67/56 ,  C07C2603/30 ,  C07C69/78

摘要： The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genus Taxus by first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40° C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50° C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.

摘要翻译： 本发明提供了一种通过首先用醇优选在20-40℃的温度下提取植物的干燥和粉碎的叶来生产属于紫杉属的植物的式I的抗癌紫杉烷类短纤维醇的方法 C.然后。 浓缩溶剂以获得醇提取物。 然后将所得醇提物用吸附剂吸附，然后将所得吸附材料在20-50℃的温度范围内干燥4-48小时。 然后将干燥的吸附材料用脂肪族溶剂和氯化溶剂的组合连续萃取并浓缩，得到残余物。 使用柱色谱法如硅胶，佛罗里达和硅酸对残余物进行粗分馏，然后用合适的吸附剂进行色谱以得到短纤维醇。