发明申请
- 专利标题: Crystalline forms of a biphenyl compound
- 专利标题(中): 联苯化合物的结晶形式
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申请号: US11715569申请日: 2007-03-08
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公开(公告)号: US20080058374A1公开(公告)日: 2008-03-06
- 发明人: YongQi Mu , Sean M. Dalziel , Yu-Hua Ji , Leticia Maria Preza
- 申请人: YongQi Mu , Sean M. Dalziel , Yu-Hua Ji , Leticia Maria Preza
- 主分类号: A61K31/445
- IPC分类号: A61K31/445 ; C07D211/06
摘要:
The invention provides crystalline forms of biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(4-hydroxybenzylamino)ethylcarbamoyl]benzoyl}methylamino)ethyl]piperidin-4-yl ester, and pharmaceutically acceptable solvates thereof. The crystalline form can be a freebase (Form I or II), a salt such as a hemiedisylate salt or a heminapadisylate salt, or a solvate of a salt such as a heminapadisylate methanolate or a heminapadisylate ethanolate. The invention also provides pharmaceutical compositions comprising these crystalline compounds or prepared using these compounds; processes and intermediates for preparing the crystalline compounds; and methods of using these compounds to treat a pulmonary disorder.
公开/授权文献
- US07973055B2 Crystalline forms of a biphenyl compound 公开/授权日:2011-07-05