发明申请
- 专利标题: 3-Carbamoyl-2-Pyridone Derivative
- 专利标题(中): 3-氨基甲酰基-2-吡啶酮衍生物
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申请号: US11628804申请日: 2005-10-28
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公开(公告)号: US20080103139A1公开(公告)日: 2008-05-01
- 发明人: Natsuki Ishizuka , Takashi Sasatani , Yoshiharu Hiramatsu , Masanao Inagaki , Masahide Odan , Hiroshi Hashizume , Susumu Mitsumori , Yasuhiko Fujii , Yoshikazu Fukui , Hideaki Watanabe , Jun Sato
- 申请人: Natsuki Ishizuka , Takashi Sasatani , Yoshiharu Hiramatsu , Masanao Inagaki , Masahide Odan , Hiroshi Hashizume , Susumu Mitsumori , Yasuhiko Fujii , Yoshikazu Fukui , Hideaki Watanabe , Jun Sato
- 优先权: JP2004-313947 20041028; JP2005-159995 20050531
- 国际申请: PCT/JP05/20248 WO 20051028
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D221/04 ; A61K31/435 ; C07D211/84 ; A61K31/4412 ; A61P17/00 ; C07D401/12 ; A61K31/496 ; A61K31/506 ; C07D413/12
摘要:
The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R1 is optionally substituted C1-C8 alkyl and the like; R2 is C1-C6 alkyl; R3 is C1-C6 alkyl and the like; or R2 and R3 taken together with may form an optionally substituted 5 to 10 membered non-aromatic carbon ring; R4 is hydrogen and the like; G is a group selected from the groups shown by the formula an the like: wherein R5 is hydrogen and the like; X1 is a single bond and the like; X2 is optionally substituted C1-C8 alkylene that may be replaced by one or two groups of —O—, or —N(R6)—, wherein R6 is hydrogen and the like, and the like; X3 is a single bond and the like; a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.
公开/授权文献
- US08178681B2 3-carbamoyl-2-pyridone derivatives 公开/授权日:2012-05-15