公开(公告)号：US20080103139A1

公开(公告)日：2008-05-01

申请号：US11628804

申请日：2005-10-28

申请人： Natsuki Ishizuka ,  Takashi Sasatani ,  Yoshiharu Hiramatsu ,  Masanao Inagaki ,  Masahide Odan ,  Hiroshi Hashizume ,  Susumu Mitsumori ,  Yasuhiko Fujii ,  Yoshikazu Fukui ,  Hideaki Watanabe ,  Jun Sato

发明人： Natsuki Ishizuka ,  Takashi Sasatani ,  Yoshiharu Hiramatsu ,  Masanao Inagaki ,  Masahide Odan ,  Hiroshi Hashizume ,  Susumu Mitsumori ,  Yasuhiko Fujii ,  Yoshikazu Fukui ,  Hideaki Watanabe ,  Jun Sato

IPC分类号： A61K31/5377 ,  C07D221/04 ,  A61K31/435 ,  C07D211/84 ,  A61K31/4412 ,  A61P17/00 ,  C07D401/12 ,  A61K31/496 ,  A61K31/506 ,  C07D413/12

CPC分类号： C07D213/82

摘要： The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R1 is optionally substituted C1-C8 alkyl and the like; R2 is C1-C6 alkyl; R3 is C1-C6 alkyl and the like; or R2 and R3 taken together with may form an optionally substituted 5 to 10 membered non-aromatic carbon ring; R4 is hydrogen and the like; G is a group selected from the groups shown by the formula an the like: wherein R5 is hydrogen and the like; X1 is a single bond and the like; X2 is optionally substituted C1-C8 alkylene that may be replaced by one or two groups of —O—, or —N(R6)—, wherein R6 is hydrogen and the like, and the like; X3 is a single bond and the like; a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

摘要翻译： 本发明提供对大麻素受体具有激动作用的化合物，其由式（I）表示：其中R 1是任选取代的C 1 -C 8烷基等; R 2是C 1 -C 6烷基; R 3是C 1 -C 6烷基等; 或R 2和R 3与相邻碳原子一起可以形成任选取代的5至10元非芳族碳环; R 4是氢等; G为选自下式的基团：其中R 5为氢等; X 1是单键等; X 2是任选取代的C 1 -C 8亚烷基，其可以被一个或两个-O-或-N（R 6） - 基团取代，其中R 0 > 6是氢等; X 3是单键等; 其药学上可接受的盐或溶剂合物，以及药物组合物，特应性皮炎治疗剂和抗瘙痒剂，特别是用于口服和外用的抗瘙痒剂，其各自含有所述化合物作为活性成分。

公开(公告)号：US20120059162A1

公开(公告)日：2012-03-08

申请号：US13192369

申请日：2011-07-27

申请人： Ken-ichi Kusakabe ,  Hiroshi Yoshida ,  Kohei Nozu ,  Hiroshi Hashizume ,  Genta Tadano ,  Jun Sato ,  Yuusuke Tamura ,  Yasunori Mitsuoka

发明人： Ken-ichi Kusakabe ,  Hiroshi Yoshida ,  Kohei Nozu ,  Hiroshi Hashizume ,  Genta Tadano ,  Jun Sato ,  Yuusuke Tamura ,  Yasunori Mitsuoka

IPC分类号： C07D487/04 ,  C07D498/04

CPC分类号： C07D487/04 ,  C07D498/04

摘要： Provided are a compound represented by general formula (1) and having a TTK inhibitory action and a medicine containing the compound. In formula (1), (X, Y, V, W) is (—N═, ═CR1—, ═N—, —CR7═), (—CR2═, ═N—, ═N—, —CR7═), etc.; A is an (un)substituted aromatic hydrocarbon ring, etc.; L is a single bond, —C(═O)—NRA—, etc.; Z is a group represented by the formula —NR3R4 or a group represented by the formula —OR5; R1 to R3, R6, and R7 each is a hydrogen atom, etc.; R4 and R5 each is an (un)substituted alkyl, etc.; and R8 is an (un)substituted cycloalkyl, etc.

摘要翻译： 提供由通式（1）表示的具有TTK抑制作用的化合物和含有该化合物的药物。 在式（1）中，（X，Y，V，W）是（-N =，= CR1-，...， - CR7 =），（-CR2 =，= N-，= N-，-CR7 = ）等 A是（未）取代的芳族烃环等; L是单键，-C（= O）-NRA-等; Z是由式-NR 3 R 4表示的基团或由式-OR 5表示的基团; R1至R3，R6和R7各自为氢原子等; R4和R5各自为（未）取代的烷基等; R8是（未）取代的环烷基等

公开(公告)号：US20120130070A1

公开(公告)日：2012-05-24

申请号：US13354881

申请日：2012-01-20

申请人： Masahiro SAKAGAMI ,  Hiroshi Hashizume ,  Satoru Tanaka

发明人： Masahiro SAKAGAMI ,  Hiroshi Hashizume ,  Satoru Tanaka

IPC分类号： C07D471/04

CPC分类号： C07D231/12 ,  C07D231/14 ,  C07D233/64 ,  C07D249/08 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D407/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

摘要： This invention provides a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R1 is substituted or unsubstituted alkyl or the like, R2 is hydrogen or substituted or unsubstituted alkyl, Ring A is monocyclic or bicyclic aromatic heterocycle, R3 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocycle, R4 is halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or the like, m is an integer between 0 and 2, n is an integer between 0 and 5, R is halogen, oxo, cyano, nitro, substituted or unsubstituted alkyl or the like, and p is an integer between 0 and 2 as novel compounds having NPY Y5 antagonistic activity.

摘要翻译： 本发明提供式（I）化合物：其药学上可接受的盐或溶剂合物，其中R 1为取代或未取代的烷基等，R 2为氢或取代或未取代的烷基，环A为单环或双环芳族杂环，R 3 取代或未取代的芳基，取代或未取代的杂芳基或取代或未取代的杂环，R4为卤素，氰基，取代或未取代的烷基，取代或未取代的环烷基等，m为0至2之间的整数，n为0 和5，R是卤素，氧代，氰基，硝基，取代或未取代的烷基等，p是0和2之间的整数，作为具有NPY Y5拮抗活性的新化合物。

公开(公告)号：US20090007426A1

公开(公告)日：2009-01-08

申请号：US12230280

申请日：2008-08-27

申请人： Hideo Aoki ,  Naoko Yamaguchi ,  Chiaki Takubo ,  Toshiaki Yamauchi ,  Koji Imamiya ,  Hiroshi Hashizume

发明人： Hideo Aoki ,  Naoko Yamaguchi ,  Chiaki Takubo ,  Toshiaki Yamauchi ,  Koji Imamiya ,  Hiroshi Hashizume

IPC分类号： H05K3/10

CPC分类号： H05K3/207 ,  G03G15/6591 ,  G03G2215/00523 ,  H05K1/095 ,  H05K3/1266 ,  H05K3/246 ,  H05K2201/0347 ,  H05K2201/09781 ,  H05K2203/0517 ,  H05K2203/105 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49155 ,  Y10T29/49165

摘要： An image forming apparatus comprises an exposure unit forming an electrostatic latent image on a photo conductor based on image information, a developing unit developing the electrostatic latent image by toner made of formation material of a circuitry layer, and an electrostatic transferring unit transferring a toner image on the photo conductor onto a substrate. The toner image is transferred so as to cover at least a part of a conductor layer formed on the substrate. At this time, excessive charges caused in the conductor layer accompanying the start of the transfer of the toner image are removed. Alternatively, charges of which polarity is reverse to that of the toner are added to the conductor layer. These allow the circuitry layer to be formed to have a desired pattern favorably and securely on the conductor layer.

摘要翻译： 图像形成装置包括基于图像信息在光导体上形成静电潜像的曝光单元，通过电路层的形成材料制成的调色剂来显影静电潜像的显影单元和转印调色剂图像的静电转印单元 在光导体上的基片上。 转印调色剂图像以覆盖形成在基板上的导体层的至少一部分。 此时，伴随着调色剂图像的转印开始导致的导体层中引起的过多的电荷被去除。 或者，将与该调色剂相反极性的电荷加到导体层中。 这些允许电路层形成为在导体层上有利地并且牢固地具有期望的图案。

公开(公告)号：US5410058A

公开(公告)日：1995-04-25

申请号：US202554

申请日：1994-02-28

申请人： Hiromu Matsumura ,  Toshisada Yano ,  Hiroshi Hashizume ,  Akira Matsushita ,  Masami Eigyo

发明人： Hiromu Matsumura ,  Toshisada Yano ,  Hiroshi Hashizume ,  Akira Matsushita ,  Masami Eigyo

IPC分类号： C07D211/70 ,  C07D211/76 ,  C07D401/12 ,  C07D409/14 ,  C07D401/06

CPC分类号： C07D401/12 ,  C07D211/70 ,  C07D211/76 ,  C07D409/14

摘要： The compounds of the present invention relates to tetrahydropyridine derivatives and have high affinity and specificity to .sigma. receptors, whereby these are thought to be effective for some psychoses.

摘要翻译： 本发明的化合物涉及四氢吡啶衍生物，并且对σ受体具有高亲和力和特异性，因此认为这些对某些精神病有效。

公开(公告)号：US5283621A

公开(公告)日：1994-02-01

申请号：US751770

申请日：1991-08-29

申请人： Hiroshi Hashizume

发明人： Hiroshi Hashizume

IPC分类号： D21G1/02 ,  F16C13/04 ,  F16C27/02 ,  G03G15/20 ,  G03G21/00

CPC分类号： F16C27/02 ,  D21G1/0226 ,  F16C13/04 ,  G03G15/206

摘要： A fixing apparatus comprises a forcibly rotated heat roller, a pressing roller rotated in contact with the heat roller, a roller shaft for supporting the pressing roller, a heater for heating the heat roller, a pair of plain bearings for supporting the roller shaft, and springs for supporting each plain bearing and urging the plain bearing towards the heat roller. According to one mode, each plain bearing has a shaft contact portion having an axial length less than that of the plain bearing. According to another mode, the roller shaft is provided with a bearing contact portion having an axial length less than that of the body of the plain bearing.

摘要翻译： 定影装置包括强制旋转的加热辊，与加热辊接触的加压辊，用于支撑加压辊的辊轴，用于加热加热辊的加热器，用于支撑辊轴的一对滑动轴承，以及 用于支撑每个滑动轴承并将滑动轴承推向加热辊的弹簧。 根据一种模式，每个滑动轴承具有轴向长度小于滑动轴承的轴接触部分的轴接触部分。 根据另一种模式，辊轴设置有轴向接触部分，其轴向长度小于滑动轴承主体的轴向长度。

公开(公告)号：US4931876A

公开(公告)日：1990-06-05

申请号：US250464

申请日：1988-09-28

申请人： Hiroshi Hashizume

发明人： Hiroshi Hashizume

IPC分类号： G03G15/24 ,  G03G15/34 ,  H04N1/29

CPC分类号： G03G15/24 ,  G03G15/344 ,  H04N1/295 ,  G03G2215/0497

摘要： An electrophotographic recording apparatus for a facsimile device in which exposure and development are performed simultaneously at the same position, and exposure, development, paper feed, rotation of the photosensitive body and fixation of the toner to the paper are performed synchronously with the receipt of image data for each line.

摘要翻译： 一种用于传真装置的电子照相记录装置，其中在相同位置同时进行曝光和显影，并且曝光，显影，进纸，感光体的旋转和调色剂固定到纸张上是与图像的接收同步地进行的 每行数据。

公开(公告)号：US4772748A

公开(公告)日：1988-09-20

申请号：US845497

申请日：1986-03-31

申请人： Hiroshi Hashizume ,  Yoshiaki Izumisawa

发明人： Hiroshi Hashizume ,  Yoshiaki Izumisawa

IPC分类号： C07C63/26 ,  C07C51/00 ,  C07C51/265 ,  C07C67/00

CPC分类号： C07C51/265

摘要： Disclosed herein is a process for producing highly pure terephthalic acid which forms polyesters of a particularly favorable color tone, the process comprising the steps ofoxidizing p-xylene, thereby obtaining a mixture containing terephthalic acid,subsequently further oxidizing the thus obtained mixture at not higher temperature than that of the first oxidation step,still further oxidizing the reaction mixture of the second oxidation step at a higher temperature than that of the first oxidation step andtreating the reaction mixture obtained by the third step of oxidation by bringing thereof into contact with molecular oxygen.

摘要翻译： 本文公开了一种生产高纯度对苯二甲酸的方法，其形成特别有利色调的聚酯，该方法包括氧化对二甲苯的步骤，从而获得含有对苯二甲酸的混合物，随后进一步氧化由此得到的混合物不高 温度比第一氧化步骤的温度高，进一步氧化第二氧化步骤的反应混合物的温度高于第一氧化步骤，并且通过使其与分子的接触处理通过第三氧化步骤获得的反应混合物 氧。

公开(公告)号：US4562285A

公开(公告)日：1985-12-31

申请号：US693232

申请日：1985-01-22

申请人： Hiroshi Hashizume ,  Yoshiaki Izumisawa

发明人： Hiroshi Hashizume ,  Yoshiaki Izumisawa

IPC分类号： C07C51/265 ,  C07C51/44 ,  C07C51/16

CPC分类号： C07C51/265 ,  C07C51/44

摘要： There is disclosed a process for producing terephthalic acid in which the mother liquor of the terephthalic acid slurry resulting from the oxidation of para-xylene, from which terephthalic acid has been separated is subjected to distillation to recover at least a portion of methyl acetate present therein, the recovered methyl acetate being circulated into the reactor.

摘要翻译： 公开了一种生产对苯二甲酸的方法，其中将对苯二甲酸氧化的对苯二甲酸浆液的母液从其中分离出对苯二甲酸进行蒸馏以回收其中存在的至少一部分乙酸甲酯 回收的乙酸甲酯循环到反应器中。

公开(公告)号：US08189796B2

公开(公告)日：2012-05-29

申请号：US11646345

申请日：2006-12-28

申请人： Hiroshi Hashizume ,  Shinji Usuba

发明人： Hiroshi Hashizume ,  Shinji Usuba

IPC分类号： H04R5/00

CPC分类号： H04M1/6041 ,  H04M1/03 ,  H04M1/6016 ,  H04M1/72522 ,  H04M3/4936 ,  H04R5/04 ,  H04R27/00 ,  H04R2227/003 ,  H04S5/00

摘要： The present invention concerns a voice response system in which a voice response unit sends a monaural voice signal corresponding to a request signal from a communication terminal to the communication terminal. The communication terminal comprises a monaural/stereo conversion portion for converting a monaural voice signal from the voice response unit to a stereo voice signal and a stereo voice outputting portion for outputting a converted stereo voice signal.

摘要翻译： 本发明涉及一种话音响应系统，其中语音应答单元将与来自通信终端的请求信号相对应的单声道语音信号发送到通信终端。 通信终端包括用于将来自语音响应单元的单声道语音信号转换为立体声声音信号的单声道/立体声转换部分和用于输出转换的立体声声音信号的立体声声音输出部分。