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    3-carbamoyl-2-pyridone derivatives
    5.
    发明授权
    3-carbamoyl-2-pyridone derivatives 有权
    3-氨基甲酰基-2-吡啶酮衍生物

    公开(公告)号：US08367666B2

    公开(公告)日：2013-02-05

    申请号：US13407520

    申请日：2012-02-28

    申请人： Takashi Sasatani ,  Yoshiharu Hiramatsu ,  Susumu Mitsumori

    发明人： Takashi Sasatani ,  Yoshiharu Hiramatsu ,  Susumu Mitsumori

    IPC分类号： A61K31/5377 ,  A61K31/435 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/506 ,  A61P17/00 ,  C07D211/84 ,  C07D221/04 ,  C07D401/12 ,  C07D413/12

    CPC分类号： C07D213/82

    摘要： The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R1, R2, R3, R4, and G are defined as herein, a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

    摘要翻译： 本发明提供对大麻素受体具有激动作用的化合物，其由式（I）表示：其中R 1，R 2，R 3，R 4和G如本文所定义，其药学上可接受的盐或溶剂合物，以及 药物组合物，特应性皮炎治疗剂和抗瘙痒剂，特别是用于口服和外用的抗瘙痒剂，其各自含有所述化合物作为活性成分。

    RING-FUSED MORPHOLINE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY
    7.
    发明申请
    RING-FUSED MORPHOLINE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY 审中-公开
    具有PI3K抑制活性的环融合吗啉衍生物

    公开(公告)号：US20110172217A1

    公开(公告)日：2011-07-14

    申请号：US13062328

    申请日：2009-09-02

    申请人： Masahiko Fujioka ,  Susumu Mitsumori ,  Akira Kugimiya ,  Daisuke Taniyama

    发明人： Masahiko Fujioka ,  Susumu Mitsumori ,  Akira Kugimiya ,  Daisuke Taniyama

    IPC分类号： A61K31/541 ,  A61K31/5383 ,  A61P29/00 ,  C07D498/04

    CPC分类号： C07D498/04 ,  A61K31/5383 ,  A61K31/541

    摘要： The present invention provides compounds or a pharmaceutically acceptable salt thereof which inhibit the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and are therefore useful for the prophylaxis/therapy of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. The above problem was solved by providing a ring-fused morpholine compound shown in the present specification, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供了抑制PI3K活性以调节包括细胞的生长，分化，存活，增殖，迁移，代谢等许多生物学过程的化合物或其药学上可接受的盐，因此可用于预防/治疗 的疾病，包括炎性疾病，动脉硬化，血管/循环系统疾病，癌症/肿瘤，免疫系统疾病，细胞增殖性疾病，感染性疾病等。 通过提供本说明书中所示的环稠合的吗啉化合物或其药学上可接受的盐来解决上述问题。