发明申请
US20080166343A1 High affinity antibody antagonists of interleukin-13 receptor alpha 1
有权
白细胞介素-13受体α1的高亲和力抗体拮抗剂
- 专利标题: High affinity antibody antagonists of interleukin-13 receptor alpha 1
- 专利标题(中): 白细胞介素-13受体α1的高亲和力抗体拮抗剂
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申请号: US11875017申请日: 2007-10-19
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公开(公告)号: US20080166343A1公开(公告)日: 2008-07-10
- 发明人: Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
- 申请人: Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/18 ; C12N15/11 ; C12N15/00 ; C12N5/06 ; A61P43/00
摘要:
High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.
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