发明申请
US20080176252A1 Amyloid beta-derived diffusible ligands (ADDLs), ADDL-surrogates, ADDL-binding molecules, and uses thereof
审中-公开
淀粉样蛋白β衍生的扩散性配体（ADDL），ADDL代用品，ADDL结合分子及其用途
- 专利标题： Amyloid beta-derived diffusible ligands (ADDLs), ADDL-surrogates, ADDL-binding molecules, and uses thereof
- 专利标题（中）： 淀粉样蛋白β衍生的扩散性配体（ADDL），ADDL代用品，ADDL结合分子及其用途
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申请号： US11142869申请日： 2005-06-01
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公开(公告)号： US20080176252A1公开(公告)日： 2008-07-24
- 发明人: Grant A. Krafft , William L. Klein , David W. Summa , Brett A. Chromy , Lei Chang , Mary P. Lambert , Kirsten L. Viola , Yuesong Gong
- 申请人： Grant A. Krafft , William L. Klein , David W. Summa , Brett A. Chromy , Lei Chang , Mary P. Lambert , Kirsten L. Viola , Yuesong Gong
- 主分类号： G01N33/567
- IPC分类号： G01N33/567 ; G01N33/566
摘要：
The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of generating ADDL-specific antibodies and methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.