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    Amyloid beta-derived diffusible ligands (ADDLs), ADDL-surrogates, ADDL-binding molecules, and uses thereof
    1.
    发明申请
    Amyloid beta-derived diffusible ligands (ADDLs), ADDL-surrogates, ADDL-binding molecules, and uses thereof 审中-公开
    淀粉样蛋白β衍生的扩散性配体（ADDL），ADDL代用品，ADDL结合分子及其用途

    公开(公告)号：US20080176252A1

    公开(公告)日：2008-07-24

    申请号：US11142869

    申请日：2005-06-01

    申请人： Grant A. Krafft ,  William L. Klein ,  David W. Summa ,  Brett A. Chromy ,  Lei Chang ,  Mary P. Lambert ,  Kirsten L. Viola ,  Yuesong Gong

    发明人： Grant A. Krafft ,  William L. Klein ,  David W. Summa ,  Brett A. Chromy ,  Lei Chang ,  Mary P. Lambert ,  Kirsten L. Viola ,  Yuesong Gong

    IPC分类号： G01N33/567 ,  G01N33/566

    CPC分类号： G01N33/6896 ,  C07K16/18

    摘要： The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of generating ADDL-specific antibodies and methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.

    摘要翻译： 本文的发明包括淀粉样蛋白β衍生的扩散配体（ADDL），包含ADDL的组合物，ADDL替代物，ADDL结合分子，以及使用任何前述化合物和组合物的方法。 ADDL包含组装成能够激活特异性细胞过程的可溶性，球状，非纤维状，寡聚结构的淀粉样蛋白β蛋白。 本发明还包括产生ADDL特异性抗体的方法和使用ADDL特异性抗体测定ADDL的形成，存在，受体蛋白结合和细胞活性的方法，以及使用这些抗体来检测阻断形成或活性的化合物 的ADDLs，以及鉴定这些化合物的方法。 本发明还提供使用ADDL特异性抗体调节ADDL形成和/或活性的方法，特别是在治疗学习和/或记忆障碍方面。