发明申请
- 专利标题： Assays and methods using biomarkers
- 专利标题（中）： 使用生物标志物的测定和方法
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申请号： US11542061申请日： 2006-10-03
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公开(公告)号： US20080182277A1公开(公告)日： 2008-07-31
- 发明人: Avi J. Ashkenazi , Klaus W. Wagner
- 申请人： Avi J. Ashkenazi , Klaus W. Wagner
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： G01N33/574
- IPC分类号： G01N33/574
摘要：
Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of GalNac-T related molecules, such as GalNac-T14 or GalNac-T3, is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Kits and articles of manufacture are also provided.
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