Transponder systems and methods for radio-over-fiber (RoF) wireless picocellular system are disclosed. One type of transponder system includes a RoF transponder used in combination with at least one radiation-reflector assembly to provide for enhanced antenna directivity of the transponder. Another type of transponder system is a transponder node assembly, wherein two or more transponders are integrated into a single assembly, thereby reducing cost while facilitating RoF wireless picocellular system deployment. Another type of transponder system provides one or more transponders in a RoF wireless picocellular system with radio-frequency identification (RFID) tags, and uses an RFID tag reader to locate and read information from the transponders, as well as to perform transponder mode selection. Another type of transponder system is directed to a tether cable assembly that includes a dispensible/retractable coiled tether cable housed in a protective housing for connecting the tether cable to a transponder.