发明申请
US20080200454A1 CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
审中-公开
碳氢化合物的联苯四唑 - 吡唑并吡啶调节剂
- 专利标题： CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
- 专利标题（中）： 碳氢化合物的联苯四唑 - 吡唑并吡啶调节剂
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申请号： US12031010申请日： 2008-02-14
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公开(公告)号： US20080200454A1公开(公告)日： 2008-08-21
- 发明人: Michael K. Ameriks , Frank U. Axe , James P. Edwards , Cheryl A. Grice , Hui Cai , Elizabeth Ann Gleason , Steven P. Meduna , Kevin L. Tays , John J. M. Wiener , Alvah T. Wickboldt
- 申请人： Michael K. Ameriks , Frank U. Axe , James P. Edwards , Cheryl A. Grice , Hui Cai , Elizabeth Ann Gleason , Steven P. Meduna , Kevin L. Tays , John J. M. Wiener , Alvah T. Wickboldt
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61P37/00 ; A61P29/00 ; A61P1/00 ; A61P25/00 ; A61P35/00 ; A61K31/496 ; A61K31/541 ; A61K31/55 ; A61P17/00 ; A61P3/10 ; A61P11/00 ; C07D471/04 ; A61K31/53
摘要：
Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.