发明申请
US20080204713A1 Methods and Apparatus for Label-Independent Monitoring of Biological Interactions on Sensitized Substrates
审中-公开
用于敏感基质上生物相互作用的标签独立监测的方法和装置
- 专利标题： Methods and Apparatus for Label-Independent Monitoring of Biological Interactions on Sensitized Substrates
- 专利标题（中）： 用于敏感基质上生物相互作用的标签独立监测的方法和装置
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申请号： US11628496申请日： 2005-06-03
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公开(公告)号： US20080204713A1公开(公告)日： 2008-08-28
- 发明人: Pierre F Indermuehle , Manfred Heidecker , Stephane Follonier , Peter Wagner
- 申请人： Pierre F Indermuehle , Manfred Heidecker , Stephane Follonier , Peter Wagner
- 国际申请： PCT/US2005/019691 WO 20050603
- 主分类号： G01N21/00
- IPC分类号： G01N21/00 ; C23F1/00 ; B29C59/00 ; G01N1/10 ; G01B9/02 ; G06F19/00 ; G01J4/00 ; B29C65/00
摘要：
Sensor interrogation systems based on optical phase changes are configured to quantify analytes. Sensor chips and wells can include light scattering regions, light absorbing regions, or tilted regions to reduce or eliminate unwanted portions of an interrogation optical beam. In some examples, a spatial phase modulation is used to compensate static birefringence or to provide a selected sensor bias point. Phase changes can be detected based on state of polarization using interferometry. Optical resonator structures can be used to enhance phase changes to simplify detection of optical phase changes.
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