发明申请
- 专利标题： Use of lytic toxins and toxin conjugates
- 专利标题（中）： 使用溶解毒素和毒素缀合物
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申请号： US11819649申请日： 2007-06-28
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公开(公告)号： US20080213310A1公开(公告)日： 2008-09-04
- 发明人: Desmond Purdy , Susan Charlton , Ian Henderson
- 申请人： Desmond Purdy , Susan Charlton , Ian Henderson
- 优先权： GBGB9926875.7 19991112
- 主分类号： A61K39/02
- IPC分类号： A61K39/02 ; C07K14/00 ; C07K16/00 ; C12P21/00 ; A61P35/00
摘要：
Agents are provided which are capable of inhibiting the cell division cycle in a target cell of interest. The agents comprise first and second components, wherein the first component is a targeting moiety which is capable of directing the second component to the target cell of interest. The second component is capable of inhibiting the cell division cycle in the target cell of interest. The agents are preferably provided in the form of conjugates, and the second component is preferably a cytolethal distending toxin. Methods for the preparation of the agents, and the use thereof for treating proliferative cell disorders and intracellular pathogens are also provided.