公开(公告)号：US07422740B1

公开(公告)日：2008-09-09

申请号：US10129558

申请日：2000-11-13

申请人： Desmond Purdy ,  Susan Charlton ,  Ian Henderson

发明人： Desmond Purdy ,  Susan Charlton ,  Ian Henderson

IPC分类号： A61K39/395 ,  A61K39/00

CPC分类号： B82Y5/00 ,  A61K47/6415 ,  A61K47/67 ,  A61K47/6829

摘要： Agents are provided which are capable of inhibiting the cell division cycle in a target cell of interest. The agents comprise first and second components, wherein the first component is a targeting moiety which is capable of directing the second component to the target cell of interest. The second component is capable of inhibiting the cell division cycle in the target cell of interest. The agents are preferably provided in the form of conjugates, and the second component is preferably a cytolethal distending toxin. Methods for the preparation of the agents, and the use thereof for treating proliferative cell disorders and intracellular pathogens are also provided.

公开(公告)号：US20080213310A1

公开(公告)日：2008-09-04

申请号：US11819649

申请日：2007-06-28

申请人： Desmond Purdy ,  Susan Charlton ,  Ian Henderson

发明人： Desmond Purdy ,  Susan Charlton ,  Ian Henderson

IPC分类号： A61K39/02 ,  C07K14/00 ,  C07K16/00 ,  C12P21/00 ,  A61P35/00

CPC分类号： B82Y5/00 ,  A61K47/6415 ,  A61K47/67 ,  A61K47/6829

摘要： Agents are provided which are capable of inhibiting the cell division cycle in a target cell of interest. The agents comprise first and second components, wherein the first component is a targeting moiety which is capable of directing the second component to the target cell of interest. The second component is capable of inhibiting the cell division cycle in the target cell of interest. The agents are preferably provided in the form of conjugates, and the second component is preferably a cytolethal distending toxin. Methods for the preparation of the agents, and the use thereof for treating proliferative cell disorders and intracellular pathogens are also provided.

摘要翻译： 提供能够抑制感兴趣的靶细胞中的细胞分裂周期的试剂。 所述试剂包含第一和第二组分，其中第一组分是靶向部分，其能够将第二组分引导至感兴趣的靶细胞。 第二组分能够抑制感兴趣的靶细胞中的细胞分裂周期。 试剂优选以缀合物的形式提供，第二组分优选为细胞致死的扩张毒素。 还提供了制备药剂的方法及其用于治疗增殖性细胞病症和细胞内病原体的用途。