发明申请
- 专利标题： AMINOAMIDES AS OREXIN ANTAGONISTS
- 专利标题（中）： AMINOAMIDES作为OREXIN ANTAGONISTS
-
申请号： US12037975申请日： 2008-02-27
-
公开(公告)号： US20080221166A1公开(公告)日： 2008-09-11
- 发明人: Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- 申请人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- 优先权： EP07103521.6 20070305
- 主分类号： A61K31/4427
- IPC分类号： A61K31/4427 ; C07C233/00 ; A61K31/165 ; C07D211/04 ; A61K31/44
摘要：
The present invention relates to compounds of formula I wherein Ar1, Ar2, Ar3, n, and R1 to R8 are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved, like sleep disorders.
公开/授权文献
- US07829563B2 Aminoamides as orexin antagonists 公开/授权日：2010-11-09