-
公开(公告)号：US20080249180A1
公开(公告)日：2008-10-09
申请号：US12044002
申请日：2008-03-07
申请人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
发明人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
IPC分类号： A61K31/165 , C07C233/01
CPC分类号： C07C233/29 , C07C233/15 , C07C233/32 , C07C233/88 , C07C2601/02 , C07C2601/08 , C07D211/16 , C07D211/46 , C07D213/40 , C07D213/75 , C07D295/185 , C07D309/14
摘要： The present invention relates to compounds of formula I wherein Ar1, Ar2, R, R1, R2, R3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved like sleep disorders.
摘要翻译： 本发明涉及式I化合物，其中Ar 1，Ar 2，R 1，R 1，R 2， >，R 3和n如本文所定义，或其药学上合适的酸加成盐，光学纯对映异构体，外消旋体或非对映体混合物。 式I化合物是食欲素受体拮抗剂，可用于治疗其中食欲素途径如睡眠障碍的疾病。
-
公开(公告)号：US20080221166A1
公开(公告)日：2008-09-11
申请号：US12037975
申请日：2008-02-27
申请人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
发明人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
IPC分类号： A61K31/4427 , C07C233/00 , A61K31/165 , C07D211/04 , A61K31/44
CPC分类号： C07D213/36 , A61K9/2018 , A61K9/4858 , C07C237/20 , C07C2601/02 , C07C2601/04
摘要： The present invention relates to compounds of formula I wherein Ar1, Ar2, Ar3, n, and R1 to R8 are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved, like sleep disorders.
摘要翻译： 本发明涉及式I化合物，其中Ar 1，Ar 2，Ar 3，n和R 1， 其中R 8和R 8如本文所定义，并且与药学上合适的酸加成盐，光学纯对映异构体，外消旋物或非对映体混合物。 这些化合物是食欲肽受体拮抗剂，并且可用于治疗涉及食欲素途径的疾病，例如睡眠障碍。
-
公开(公告)号：US07396853B2
公开(公告)日：2008-07-08
申请号：US11492462
申请日：2006-07-25
IPC分类号： A61K31/404 , C07D209/38
CPC分类号： C07D209/38 , C07C59/56 , C07C69/732 , C07D209/34 , C07D307/83 , C07D307/84
摘要： The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims, which compounds are active on the GABAB receptor and are useful in the control or prevention of CNS illnesses, especially of illnesses and disorders comprising anxiety, depression, epilepsy, schizophrenia, and cognitive disorders.
摘要翻译： 本发明涉及式I化合物：其中R 1，R 2，R 3，R 4， R 5和R 6如说明书和权利要求中所定义，该化合物在GABA B受体上具有活性，并且可用于 控制或预防CNS疾病，特别是包括焦虑，抑郁，癫痫，精神分裂症和认知障碍的疾病和病症。
-
公开(公告)号：US20070027204A1
公开(公告)日：2007-02-01
申请号：US11492462
申请日：2006-07-25
IPC分类号： A61K31/404 , A61K31/365 , A61K31/192
CPC分类号： C07D209/38 , C07C59/56 , C07C69/732 , C07D209/34 , C07D307/83 , C07D307/84
摘要： The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims, which compounds are active on the GABAB receptor and are useful in the control or prevention of CNS illnesses, especially of illnesses and disorders comprising anxiety, depression, epilepsy, schizophrenia, and cognitive disorders.
摘要翻译： 本发明涉及式I化合物：其中R 1，R 2，R 3，R 4， R 5和R 6如说明书和权利要求中所定义，该化合物在GABA B受体上具有活性，并且可用于 控制或预防CNS疾病，特别是包括焦虑，抑郁，癫痫，精神分裂症和认知障碍的疾病和病症。
-
公开(公告)号：US08067598B2
公开(公告)日：2011-11-29
申请号：US12056324
申请日：2008-03-27
申请人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
发明人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
IPC分类号： C07D471/04 , C07D513/04 , A61K31/4365 , A61K31/437 , A61K31/4375
CPC分类号： C07D471/04 , C07D495/04
摘要： The present invention relates to compounds of formula wherein R1, R2, R3, and R4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring system, connected to the carbon atoms of the piperidine group selected from the group consisting of or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders in which orexin pathways are involved, like sleep disorders.
摘要翻译： 本发明涉及下式的化合物，其中R 1，R 2，R 3和R 4如本文所定义，杂芳基是与哌啶基团的碳原子连接的一个或两个环 - 元杂芳族环系统，所述哌啶基团的碳原子选自 或其药学上合适的酸加成盐，旋光纯对映异构体，外消旋体或非对映体混合物。 这些化合物是食欲素受体拮抗剂，并且可用于治疗涉及食欲素途径的疾病，例如睡眠障碍。
-
公开(公告)号：US07728142B2
公开(公告)日：2010-06-01
申请号：US11444770
申请日：2006-06-01
IPC分类号： C07D215/38
CPC分类号： C07D265/22 , C07D215/36 , C07D215/38 , C07D215/42 , C07D401/04
摘要： The present invention relates to compounds of formula I wherein R1, R2 and R3 are as defined in the specification, which are active at the GABAB receptor and which can be used for the treatment of CNS disorders.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3如说明书中所定义，其在GABA B受体上是有活性的并且可用于治疗CNS紊乱。
-
公开(公告)号：US07576217B2
公开(公告)日：2009-08-18
申请号：US11259860
申请日：2005-10-27
申请人： Parichehr Malherbe , Raffaello Masciadri , Roger David Norcross , Hasane Ratni , Andrew William Thomas
发明人： Parichehr Malherbe , Raffaello Masciadri , Roger David Norcross , Hasane Ratni , Andrew William Thomas
IPC分类号： C07D215/38
CPC分类号： C07D215/38 , C07D215/18 , C07D215/20 , C07D401/04
摘要： The present invention relates to compounds of formula I wherein R1 to R6 are as described herein, which compounds are active at the GABAB receptor and can be used for the preparation of medicaments useful in the treatment of CNS disorders comprising anxiety and depression.
摘要翻译： 本发明涉及其中R 1至R 6如本文所述的式I化合物，该化合物在GABA B受体上具有活性，并且可用于制备用于治疗包括焦虑和抑郁症的CNS病症的药物。
-
公开(公告)号：US07829563B2
公开(公告)日：2010-11-09
申请号：US12037975
申请日：2008-02-27
申请人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
发明人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
IPC分类号： A61K31/50 , A61K31/501 , A61K31/497 , A01N43/54 , C07D239/42 , C07D401/04 , A01N43/40 , A61K31/435 , A01N43/78 , A61K31/425 , A01N43/50 , A61K31/415 , A01N43/56 , A01N43/08 , A61K31/34 , C07D279/00 , C07D285/00 , C07D401/00 , C07D421/00 , C07D419/00 , C07D277/04 , C07D277/08 , C07D409/00 , C07D335/00 , C07D333/02 , C07D321/00 , C07D307/00 , C07D317/00 , C07D323/02
CPC分类号： C07D213/36 , A61K9/2018 , A61K9/4858 , C07C237/20 , C07C2601/02 , C07C2601/04
摘要： The present invention relates to compounds of formula I wherein Ar1, Ar2, Ar3, n, and R1 to R8 are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved, like sleep disorders.
摘要翻译： 本发明涉及式I化合物，其中Ar1，Ar2，Ar3，n和R1至R8如本文所定义，以及其药学上合适的酸加成盐，光学纯对映异构体，外消旋体或非对映体混合物。 这些化合物是食欲肽受体拮抗剂，并且可用于治疗涉及食欲素途径的疾病，例如睡眠障碍。
-
公开(公告)号：US07504428B2
公开(公告)日：2009-03-17
申请号：US12130256
申请日：2008-05-30
IPC分类号： A61K31/404 , A61K31/343
CPC分类号： C07D209/38 , C07C59/56 , C07C69/732 , C07D209/34 , C07D307/83 , C07D307/84
摘要： The present invention a method of treating anxiety by administering compounds that are active on the GABAB receptor, having formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims.
摘要翻译： 本发明通过给予具有式I的GABA B受体上具有活性的化合物来治疗焦虑的方法：其中R1，R2，R3，R4，R5和R6如说明书和权利要求中所定义。
-
公开(公告)号：US07501541B2
公开(公告)日：2009-03-10
申请号：US12044002
申请日：2008-03-07
申请人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
发明人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
IPC分类号： C07C233/05 , A61K31/65
CPC分类号： C07C233/29 , C07C233/15 , C07C233/32 , C07C233/88 , C07C2601/02 , C07C2601/08 , C07D211/16 , C07D211/46 , C07D213/40 , C07D213/75 , C07D295/185 , C07D309/14
摘要： The present invention relates to compounds of formula I wherein Ar1, Ar2, R, R1, R2, R3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved like sleep disorders.
摘要翻译： 本发明涉及式I化合物，其中Ar1，Ar2，R，R1，R2，R3和n如本文所定义，或其药学上合适的酸加成盐，光学纯对映异构体，外消旋物或非对映体混合物。 式I化合物是食欲素受体拮抗剂，可用于治疗其中食欲素途径如睡眠障碍的疾病。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.019 秒)
