发明申请
- 专利标题： Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and DNA coding for the same
- 专利标题（中）： 具有支持造血干细胞和造血祖细胞的增殖或存活的活性的多肽和编码其的DNA
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申请号： US11986709申请日： 2007-11-26
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公开(公告)号： US20080227200A1公开(公告)日： 2008-09-18
- 发明人: Radoje T. Drmanac , Ivan Labat , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain , Mitsuo Nishikawa
- 申请人： Radoje T. Drmanac , Ivan Labat , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain , Mitsuo Nishikawa
- 主分类号： C12N5/06
- IPC分类号： C12N5/06 ; C12N15/11 ; C07K14/00 ; C07K16/18 ; C12N15/00
摘要：
A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.
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