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公开(公告)号：US20130244927A1
公开(公告)日：2013-09-19
申请号：US13397592
申请日：2012-02-15
申请人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
发明人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译： 本发明提供了人信号肽肽蛋白（HSPP）和识别和编码HSPP的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。
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公开(公告)号：US07674890B2
公开(公告)日：2010-03-09
申请号：US12080212
申请日：2008-04-01
申请人： Bryan J. Boyle , Peter C. R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
发明人： Bryan J. Boyle , Peter C. R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
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公开(公告)号：US07608704B2
公开(公告)日：2009-10-27
申请号：US11378616
申请日：2006-03-20
申请人： Henry Yue , Monique G. Yao , Ameena R. Gandhi , Mariah R. Baughn , Anita Swarnakar , Narinder Chawla , Madhusudan M. Sanjanwala , Michael Thorton , Vicki S. Elliott , Yan Lu , Kimberly J. Gietzen , Neil Burford , Li Ding , April J. A. Hafalia , Y. Tom Tang , Olga Bandman , Bridget A. Warren , Cynthia D. Honchell , Dyung Aina M. Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti G. Lal , Bao Tran , Craig H. Ison , Brendan M. Duggan , Stephanie K. Sapperstein
发明人： Henry Yue , Monique G. Yao , Ameena R. Gandhi , Mariah R. Baughn , Anita Swarnakar , Narinder Chawla , Madhusudan M. Sanjanwala , Michael Thorton , Vicki S. Elliott , Yan Lu , Kimberly J. Gietzen , Neil Burford , Li Ding , April J. A. Hafalia , Y. Tom Tang , Olga Bandman , Bridget A. Warren , Cynthia D. Honchell , Dyung Aina M. Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti G. Lal , Bao Tran , Craig H. Ison , Brendan M. Duggan , Stephanie K. Sapperstein
CPC分类号： C12N15/1055 , A61K39/3955 , A61K47/64 , A61K47/643 , A61K2039/505 , C07K14/47 , C07K14/4711 , C07K14/4713 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/5023
摘要： The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
摘要翻译： 本发明提供鉴定和编码SECP的人分泌蛋白（SECP）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与SECP异常表达相关的疾病的方法。
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4.发明申请METHODS OF THERAPY AND DIAGNOSIS USING TARGETING OF CELLS THAT EXPRESS KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR-LIKE PROTEINS 审中-公开使用表达杀伤细胞免疫抑制蛋白样受体样蛋白的细胞靶向的治疗方法和诊断方法公开(公告)号：US20090081209A1
公开(公告)日：2009-03-26
申请号：US12024226
申请日：2008-02-01
申请人： PETER C.R. EMTAGE , Y. TOM TANG
发明人： PETER C.R. EMTAGE , Y. TOM TANG
IPC分类号： A61K39/395 , C07K16/18 , A61K31/7105 , A61K39/00 , A61K38/02 , A61P35/02 , C12Q1/68 , C07H21/00 , C12N15/63 , C12N5/10 , C07K2/00
CPC分类号： C07K14/705 , A61K38/00 , A61K47/6849 , A61K48/00 , A61K51/1027 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/34 , C07K2317/732 , C07K2317/77 , C07K2319/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57426 , G01N33/6872 , G01N2333/70503
摘要： Certain cells, including various types of cancer cells, express KIRHy proteins. Targeting using KIRHy polypeptides, nucleic acids encoding for KIRHy polypeptides and anti-KIRHy antibodies provides a method of killing or inhibiting that growth of cancer cells that express the KIRHy protein. Methods of therapy and diagnosis of disorders associated with KIRHy protein-expressing cells, such as acute myelogenous leukemia (AML), are described.
摘要翻译： 某些细胞，包括各种类型的癌细胞，表达KIRHy蛋白。 使用KIRHy多肽进行靶向，编码KIRHy多肽的核酸和抗KIRHy抗体提供了杀死或抑制表达KIRHy蛋白的癌细胞生长的方法。 描述了与KIRHy蛋白表达细胞相关的疾病如急性骨髓性白血病（AML）的治疗和诊断方法。
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5.发明申请Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides 审中-公开与干细胞生长因子样多肽和多核苷酸相关的方法和材料公开(公告)号：US20090075877A1
公开(公告)日：2009-03-19
申请号：US12075713
申请日：2008-03-13
申请人： Y. Tom Tang
发明人： Y. Tom Tang
CPC分类号： C07K14/475
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or versants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，以及与新型人分泌的干细胞生长因子样多肽相对应的突变体或多肽。 本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。
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6.发明申请Methods and Materials Relating to CD84-like Polypeptides and Polynucelotides 有权与CD84样多肽和多聚核糖核酸相关的方法和材料公开(公告)号：US20090023659A1
公开(公告)日：2009-01-22
申请号：US12195282
申请日：2008-08-20
申请人： Chiaoyun Kuo , Bryan J. Boyle , Jian Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Chiaoyun Kuo , Bryan J. Boyle , Jian Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： A61K38/17 , G01N33/53 , C12P21/02 , A61K31/7088 , C12Q1/68
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人分泌的CD84样多肽的这种多核苷酸及其突变体或变体编码的新的多核苷酸和多肽。 这些多核苷酸包含从人脾cDNA文库中分离的核酸序列（Hyseq克隆鉴定号2938352（SEQ ID NO：1））。 本发明的其它方面包括含有生产新的人分泌的CD84样多肽的方法的载体和对这些多肽特异的抗体。
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公开(公告)号：US20080300183A1
公开(公告)日：2008-12-04
申请号：US11805883
申请日：2007-05-24
申请人： Bryan J. Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Y. Tom Tang , Mikio Yagi , Kazuma Tomizuka
发明人： Bryan J. Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Y. Tom Tang , Mikio Yagi , Kazuma Tomizuka
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A61K38/1709 , A61K48/005 , C07K14/475 , C12N15/8509 , C12N2799/022 , C12N2800/30
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译： 本发明涉及包含胃肠增生因子（GIPF）多核苷酸和多肽的药物组合物。 本发明还涉及GIPF用于预防或治疗与上皮粘膜变性相关的病症或病症的治疗用途。
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公开(公告)号：US07439327B2
公开(公告)日：2008-10-21
申请号：US11334081
申请日：2006-01-17
申请人： Bryan J. Boyle , Peter C. R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
发明人： Bryan J. Boyle , Peter C. R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译： 本发明涉及包含胃肠增生因子SCFA2，SCFA4或SCFA4v多核苷酸和多肽的药物组合物。 本发明还涉及SCFA2，SCFA4或SCFA4v用于预防或治疗与上皮粘膜退化相关的病症或障碍的治疗用途。
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公开(公告)号：US20080187961A1
公开(公告)日：2008-08-07
申请号：US11905820
申请日：2007-10-04
申请人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
发明人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译： 本发明提供了人信号肽肽蛋白（HSPP）和识别和编码HSPP的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。
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公开(公告)号：US07371832B1
公开(公告)日：2008-05-13
申请号：US09744196
申请日：1999-07-21
申请人： Y. Tom Tang , Preeti Lal , Jennifer L. Hillman , Neil C. Corley , Chandra Arvizu , Mariah R. Baughn
发明人： Y. Tom Tang , Preeti Lal , Jennifer L. Hillman , Neil C. Corley , Chandra Arvizu , Mariah R. Baughn
CPC分类号： C07K14/4702 , A61K38/00
摘要： The invention provides human molecules associated with cell proliferation (MACP) and polynucleotides which identify and encode MACP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of MACP.
摘要翻译： 本发明提供与细胞增殖相关的人分子（MACP）和识别和编码MACP的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了用于诊断，治疗或预防与MACP表达相关的障碍的方法。
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