发明申请
- 专利标题： Irta-2 Antibodies and Their Uses
- 专利标题（中）： Irta-2抗体及其用途
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申请号： US11794606申请日： 2006-01-12
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公开(公告)号： US20080247944A1公开(公告)日： 2008-10-09
- 发明人: Robert Graziano , David J. King , Mohan Srinivasan , Josephine M. Cardarelli , Haichun Huang
- 申请人： Robert Graziano , David J. King , Mohan Srinivasan , Josephine M. Cardarelli , Haichun Huang
- 国际申请： PCT/US06/01444 WO 20060112
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; C07K16/18 ; C12N15/00 ; C12P21/04 ; A61P43/00 ; C12N5/06 ; A61K39/395
摘要：
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-2, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
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