发明申请
US20080254495A1 Method of Diagnosing Apoplectic Stroke/Asymptomatic Brain Infarction Using Polyamine and Acrolein Contents, Polyamine Oxidase Activity or Protein Content Thereof as Indication
有权
使用多胺和丙烯醛含量诊断卒中/无症状性脑梗死的方法，多胺氧化酶活性或其蛋白质含量作为指标
- 专利标题： Method of Diagnosing Apoplectic Stroke/Asymptomatic Brain Infarction Using Polyamine and Acrolein Contents, Polyamine Oxidase Activity or Protein Content Thereof as Indication
- 专利标题（中）： 使用多胺和丙烯醛含量诊断卒中/无症状性脑梗死的方法，多胺氧化酶活性或其蛋白质含量作为指标
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申请号： US10599221申请日： 2005-03-25
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公开(公告)号： US20080254495A1公开(公告)日： 2008-10-16
- 发明人: Kazuel Igarashi , Shiro Ueda , Naokatsu Saeki , Keiko Kashiwagi , Hideyuki Tomitori
- 申请人： Kazuel Igarashi , Shiro Ueda , Naokatsu Saeki , Keiko Kashiwagi , Hideyuki Tomitori
- 申请人地址： JP Tokyo
- 专利权人： FUENCE CO., LTD.
- 当前专利权人： FUENCE CO., LTD.
- 当前专利权人地址： JP Tokyo
- 优先权： JP2004-089063 20040325; JP2004-255976 20040902
- 国际申请： PCT/JP2005/006429 WO 20050325
- 主分类号： C12Q1/26
- IPC分类号： C12Q1/26 ; C12Q1/02
摘要：
The present invention provides a diagnostic method for stroke/asymptomatic cerebral infarction and a screening method for patients with stroke/asymptomatic cerebral infarction, which comprise measuring acrolein content or polyamine content; or polyamine oxidase activity or protein content of polyamine oxidase in plasma. The knowledge of the present invention indicates the possibility of preventing, inhibiting the progression of stroke/asymptomatic cerebral infarction by inhibiting polyamine oxidase, and the possibility of obtaining a therapeutic agent for stroke/asymptomatic cerebral infarction by searching for compounds that inhibit polyamine oxidase.
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