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    Method of diagnosing apoplectic stroke/asymptomatic brain infarction using acrolein content
    2.
    发明授权
    Method of diagnosing apoplectic stroke/asymptomatic brain infarction using acrolein content 有权
    使用丙烯醛含量诊断卒中/无症状性脑梗死的方法

    公开(公告)号：US08715921B2

    公开(公告)日：2014-05-06

    申请号：US10599221

    申请日：2005-03-25

    申请人： Kazuei Igarashi ,  Shiro Ueda ,  Naokatsu Saeki ,  Keiko Kashiwagi ,  Hideyuki Tomitori

    发明人： Kazuei Igarashi ,  Shiro Ueda ,  Naokatsu Saeki ,  Keiko Kashiwagi ,  Hideyuki Tomitori

    IPC分类号： C12Q1/00

    CPC分类号： C12Q1/26 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2800/2871

    摘要： The present invention provides a diagnostic method for stroke/asymptomatic cerebral infarction and a screening method for patients with stroke/asymptomatic cerebral infarction, which comprise measuring acrolein content or polyamine content; or polyamine oxidase activity or protein content of polyamine oxidase in plasma. The knowledge of the present invention indicates the possibility of preventing, inhibiting the progression of stroke/asymptomatic cerebral infarction by inhibiting polyamine oxidase, and the possibility of obtaining a therapeutic agent for stroke/asymptomatic cerebral infarction by searching for compounds that inhibit polyamine oxidase.

    摘要翻译： 本发明提供脑卒中/无症状性脑梗死的诊断方法和中风/无症状脑梗死患者的筛查方法，其中包括测量丙烯醛含量或多胺含量; 或多胺氧化酶活性或多胺氧化酶在血浆中的蛋白质含量。 本发明的知识表明通过抑制多胺氧化酶抑制中风/无症状性脑梗死发展的可能性，以及通过搜索抑制多胺氧化酶的化合物获得中风/无症状性脑梗死治疗剂的可能性。

    POLYPEPTIDE MARKER FOR DIAGNOSIS OF ARTERIOSCLEROSIS, METHOD FOR DETECTION OF ARTERIOSCLEROSIS BY USING THE MAKER OR THE LIKE, AND KIT FOR DIAGNOSIS OF ARTERIOSCLEROSIS
    3.
    发明申请
    POLYPEPTIDE MARKER FOR DIAGNOSIS OF ARTERIOSCLEROSIS, METHOD FOR DETECTION OF ARTERIOSCLEROSIS BY USING THE MAKER OR THE LIKE, AND KIT FOR DIAGNOSIS OF ARTERIOSCLEROSIS 审中-公开
    用于诊断病原体的多肽标记物，使用制造商或类似物检测肠梗塞的方法以及用于诊断椎间盘菌的试剂盒

    公开(公告)号：US20110287955A1

    公开(公告)日：2011-11-24

    申请号：US13058456

    申请日：2009-08-14

    申请人： Rika Nakamura ,  Hideyuki Kuroda ,  Go Tomiyoshi ,  Takaki Hiwasa ,  Masaki Takiguchi ,  Naokatsu Saeki ,  Toshio Machida

    发明人： Rika Nakamura ,  Hideyuki Kuroda ,  Go Tomiyoshi ,  Takaki Hiwasa ,  Masaki Takiguchi ,  Naokatsu Saeki ,  Toshio Machida

    IPC分类号： C40B30/04 ,  C40B40/06 ,  C07K14/435 ,  C12Q1/68 ,  C07K16/18 ,  C07H21/04 ,  G01N33/566

    CPC分类号： G01N33/6893 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/323

    摘要： Disclosed are: a polypeptide marker for diagnosing arteriosclerosis; a gene marker for diagnosing arteriosclerosis; an antibody; a probe for detecting an arteriosclerosis marker gene; a DNA microarray or a DNA chip for detecting an arteriosclerosis marker gene; a method for detecting arteriosclerosis; and a kit for diagnosing arteriosclerosis; with which an arteriosclerotic lesion can be detected with much improved accuracy. Specifically disclosed are: a polypeptide marker for diagnosing arteriosclerosis, which comprises a polypeptide having an amino acid sequence set forth in any one of SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, and 35 of the Sequence Listing, or a partial amino acid sequence thereof; a gene which encodes the amino acid sequence; a probe for detecting the gene; a DNA microarray or a DNA chip comprising the probe; an antibody bindable to the polypeptide as an antigen; a kit comprising any one of the above-mentioned items; and a method for detecting arteriosclerosis by using any one of the above-mentioned items.

    摘要翻译： 公开了用于诊断动脉硬化的多肽标记物; 用于诊断动脉硬化的基因标记物; 抗体; 用于检测动脉硬化标志物基因的探针; 用于检测动脉硬化标志物基因的DNA微阵列或DNA芯片; 检测动脉硬化的方法; 和用于诊断动脉硬化的试剂盒; 可以以更高的精度检测动脉硬化病变。 具体公开的是：用于诊断动脉硬化的多肽标记物，其包含具有SEQ ID NO：1,3,5,7,9,11,13,15,17,19， 21,23,25,27,29,31,33和35，或其部分氨基酸序列; 编码氨基酸序列的基因; 用于检测基因的探针; DNA微阵列或包含探针的DNA芯片; 可与该多肽结合的抗体作为抗原; 一个包括上述任何项目的工具包; 以及通过使用上述任一个项目来检测动脉硬化的方法。