发明申请
- 专利标题： TETRAHYDRO-NAPHTHALENE DERIVATIVES
- 专利标题（中）： 四氢萘衍生物
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申请号： US12103396申请日： 2008-04-15
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公开(公告)号： US20080275047A1公开(公告)日： 2008-11-06
- 发明人: Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
- 申请人： Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
- 优先权： EP02027523.6 20021206
- 主分类号： A61K31/5375
- IPC分类号： A61K31/5375 ; A61K31/17 ; A61P13/00 ; A61K31/167
摘要：
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tethrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontienence, chronic pain, neuropathic pain, post-operative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
公开/授权文献
- US08088826B2 Tetrahydro-naphthalene derivatives 公开/授权日：2012-01-03
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