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    2-naphthamide derivatives
    7.
    发明申请
    2-naphthamide derivatives 审中-公开
    2-萘甲酰胺衍生物

    公开(公告)号：US20060166989A1

    公开(公告)日：2006-07-27

    申请号：US10517677

    申请日：2003-05-30

    Applicant: Makoto Shimazaki ,  Osamu Sakurai ,  Toshiki Murata ,  Klaus Urbahns ,  Noriyuki Yamamoto ,  Satoru Yoshikawa ,  Masaomi Umeda ,  Masaomi Tajimi ,  Tsutomu Masuda ,  Takuya Shintani ,  Haruka Shimizu

    Inventor： Makoto Shimazaki ,  Osamu Sakurai ,  Toshiki Murata ,  Klaus Urbahns ,  Noriyuki Yamamoto ,  Satoru Yoshikawa ,  Masaomi Umeda ,  Masaomi Tajimi ,  Tsutomu Masuda ,  Takuya Shintani ,  Haruka Shimizu

    IPC: A61K31/537 ,  A61K31/44 ,  A61K31/195 ,  C07D213/55 ,  C07D265/30 ,  C07C237/40

    CPC classification number: C07C235/66

    Abstract: The present invention relates to 2-naphthamides, which are useful as an active ingredient of pharmaceutical preparations. The 2-naphthamides of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor activity. Such diseases include urological diseases or disorder as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benign prostatic hypertrophy (BPH), pro-statitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since the disease is also alleviated by treatment with an IP receptor antagonist.

    Abstract translation: 本发明涉及可用作药物制剂活性成分的2-萘甲酰胺。 本发明的2-萘甲酰胺具有IP受体拮抗活性，可用于预防和治疗与IP受体活性相关的疾病。 这些疾病包括尿路疾病或病症如下：膀胱出口阻塞，膀胱过度活动，尿失禁，逼尿肌反射反射，逼尿肌不稳定，膀胱容量减少，排尿频率，急迫性尿失禁，压力性尿失禁，膀胱高反应性，良性前列腺肥大 ），pro-statitis，尿频，夜尿症，尿急，盆腔超敏反应，尿道炎，盆腔疼痛综合征，前列腺增生症，膀胱炎或自发性膀胱过敏反应。 本发明的化合物还可用于治疗疼痛，包括但不限于炎性疼痛，神经性疼痛，急性疼痛，慢性疼痛，牙痛，经前痛，内脏痛，头痛等; 低血压 血友病和出血; 和炎症，因为该疾病也通过用IP受体拮抗剂治疗而缓解。

    Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist
    8.
    发明申请
    Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist 审中-公开
    苯基或杂芳基氨基烷烃衍生物作为ip受体拮抗剂

    公开(公告)号：US20060089371A1

    公开(公告)日：2006-04-27

    申请号：US10534174

    申请日：2003-10-29

    Applicant: Toshiki Murata ,  Masami Umeda ,  Satoru Yoshikawa ,  Klaus Urbahns ,  Jang Gupta ,  Osamu Sakurai

    Inventor： Toshiki Murata ,  Masami Umeda ,  Satoru Yoshikawa ,  Klaus Urbahns ,  Jang Gupta ,  Osamu Sakurai

    IPC: A61K31/506 ,  C07D403/02

    CPC classification number: C07D213/64 ,  C07C229/36 ,  C07D213/74 ,  C07D231/38 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D277/42 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/10

    Abstract: The present invention relates to phenyl or heteroaryl amino alkane derivatives of formula (I) in which the groups Q1-Q4, Ar, and R1-R7 are as defined in the specification and claims. These materials are useful as active ingredients of pharmaceutical preparations. The phenyl or heteroaryl amino alkanes of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity. Such diseases include urological diseases or disorders as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since these diseases also are alleviated by treatment with an IP receptor antagonist. The application claims the compounds, pharmaceutical compositions containing them, and methods of treatment using them.

    Abstract translation: 本发明涉及式（I）的苯基或杂芳基氨基烷烃衍生物，其中基团Q 1，Q 4，Ar和R 1， SUP> -R 7如说明书和权利要求中所定义。 这些材料可用作药物制剂的活性成分。 本发明的苯基或杂芳基氨基烷烃具有IP受体拮抗活性，可用于预防和治疗与IP受体拮抗活性相关的疾病。 这些疾病包括泌尿系统疾病或疾病如下：膀胱出口阻塞，膀胱过度活动，尿失禁，逼尿肌反射反射，逼尿肌不稳定，膀胱容量减少，排尿频率，急迫性尿失禁，压力性尿失禁，膀胱高反应性，良性前列腺肥大 ），前列腺炎，尿频，夜尿症，尿急，盆腔超敏反应，尿道炎，盆腔疼痛综合征，前列腺痛，膀胱炎或自发性膀胱过敏。 本发明的化合物还可用于治疗疼痛，包括但不限于炎性疼痛，神经性疼痛，急性疼痛，慢性疼痛，牙痛，经前痛，内脏痛，头痛等; 低血压 血友病和出血; 和炎症，因为这些疾病也通过用IP受体拮抗剂治疗而缓解。 本申请要求化合物，含有它们的药物组合物和使用它们的治疗方法。

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