发明申请
US20080280856A1 Fibroblast Activation Protein Inhibitor Compounds and Methods
审中-公开
成纤维细胞激活蛋白抑制剂化合物和方法
- 专利标题: Fibroblast Activation Protein Inhibitor Compounds and Methods
- 专利标题(中): 成纤维细胞激活蛋白抑制剂化合物和方法
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申请号: US12133148申请日: 2008-06-04
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公开(公告)号: US20080280856A1公开(公告)日: 2008-11-13
- 发明人: Frederick Cohen , Wayne J. Fairbrother , Clifford Quan , Daniel P. Sutherlin , Beni B. Wolf
- 申请人: Frederick Cohen , Wayne J. Fairbrother , Clifford Quan , Daniel P. Sutherlin , Beni B. Wolf
- 申请人地址: US CA South San Francisco
- 专利权人: Genentech, Inc.
- 当前专利权人: Genentech, Inc.
- 当前专利权人地址: US CA South San Francisco
- 主分类号: A61K31/69
- IPC分类号: A61K31/69 ; C07F5/02 ; C07D213/02 ; A61P9/00 ; A61P17/00 ; A61P37/00 ; A61P29/00 ; A61P25/00 ; A61P35/00 ; C07D207/00
摘要:
Amino terminus-blocked peptide boronate compounds of Formulas I and II are useful for inhibiting Fibroblast Activation Protein (FAP) and other proteases, and for treating disorders mediated by FAP. Methods of using the amino terminus blocked peptide boronate compounds, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.