发明申请
US20080306030A1 Use of a TRPM5 Inhibitor to Regulate Insulin and GLP-1 Release
有权
使用TRPM5抑制剂调节胰岛素和GLP-1释放
- 专利标题： Use of a TRPM5 Inhibitor to Regulate Insulin and GLP-1 Release
- 专利标题（中）： 使用TRPM5抑制剂调节胰岛素和GLP-1释放
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申请号： US12025488申请日： 2008-02-04
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公开(公告)号： US20080306030A1公开(公告)日： 2008-12-11
- 发明人: S. Paul Lee , Peihong Zhou , M.N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
- 申请人： S. Paul Lee , Peihong Zhou , M.N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
- 申请人地址： US NJ Ewing
- 专利权人： Redpoint Bio Corporation
- 当前专利权人： Redpoint Bio Corporation
- 当前专利权人地址： US NJ Ewing
- 主分类号： A61K31/15
- IPC分类号： A61K31/15 ; A61K31/655 ; A61K31/47 ; A61K31/4409 ; A61K31/438 ; A61P3/00 ; A61P1/00 ; C12N5/00 ; A61K31/5375 ; A61K31/165 ; A61K31/404
摘要：
The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
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