发明申请
US20080306091A1 AMINO-5-(5-MEMBERED)HETERO-ARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR beta-SECRETASE MODULATION
失效
AMINO-5-（5-MEMBERED）异星形霉素化合物及其用于β-分泌酶调节的用途
- 专利标题： AMINO-5-(5-MEMBERED)HETERO-ARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR beta-SECRETASE MODULATION
- 专利标题（中）： AMINO-5-（5-MEMBERED）异星形霉素化合物及其用于β-分泌酶调节的用途
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申请号： US12180795申请日： 2008-07-28
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公开(公告)号： US20080306091A1公开(公告)日： 2008-12-11
- 发明人: Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
- 申请人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 主分类号： C07D403/10
- IPC分类号： C07D403/10 ; A61K31/506 ; C07D401/10 ; A61K31/4439 ; A61K31/4152 ; A61K31/4168 ; A61K31/4178 ; C07D233/96 ; C07D231/10 ; C07D413/10 ; A61K31/5377
摘要：
The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
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