发明申请
US20080312221A1 QUINOLINE DERIVATIVE AND QUINAZOLINE DERIVATIVE INHIBITING SELF-PHOSPHORYLATION OF HEPATOCYTUS PROLIFERATOR RECEPTOR, AND MEDICINAL COMPOSITION CONTAINING THE SAME
审中-公开
喹诺酮衍生物和喹唑啉衍生物抑制肝细胞增生物受体的自体磷酸化，以及含有其的药物组合物
- 专利标题： QUINOLINE DERIVATIVE AND QUINAZOLINE DERIVATIVE INHIBITING SELF-PHOSPHORYLATION OF HEPATOCYTUS PROLIFERATOR RECEPTOR, AND MEDICINAL COMPOSITION CONTAINING THE SAME
- 专利标题（中）： 喹诺酮衍生物和喹唑啉衍生物抑制肝细胞增生物受体的自体磷酸化，以及含有其的药物组合物
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申请号： US12175361申请日： 2008-07-17
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公开(公告)号： US20080312221A1公开(公告)日： 2008-12-18
- 发明人: Yasunari Fujiwara , Terufumi Senga , Tsuyoshi Nishitoba , Tatsushi Osawa , Atsushi Miwa , Kazuhide Nakamura
- 申请人： Yasunari Fujiwara , Terufumi Senga , Tsuyoshi Nishitoba , Tatsushi Osawa , Atsushi Miwa , Kazuhide Nakamura
- 申请人地址： JP Tokyo-To
- 专利权人： KIRIN BEER KABUSHIKI KAISHA
- 当前专利权人： KIRIN BEER KABUSHIKI KAISHA
- 当前专利权人地址： JP Tokyo-To
- 优先权： JP2001-190238 20010622
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; C07D215/233 ; C07D413/12 ; A61K31/541 ; A61P35/00 ; A61K31/5377 ; C07D417/12
摘要：
An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.
公开/授权文献
- US3162778A Electric thermal generator 公开/授权日：1964-12-22
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