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    Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors
    4.
    发明授权
    Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors 失效
    喹啉或喹唑啉衍生物抑制成纤维细胞生长因子受体的自身磷酸化

    公开(公告)号：US07495104B2

    公开(公告)日：2009-02-24

    申请号：US10491898

    申请日：2002-10-17

    申请人： Atsushi Miwa ,  Tetsuya Yoshino ,  Tatsushi Osawa ,  Teruyuki Sakai ,  Toshiyuki Shimizu ,  Yasunari Fujiwara

    发明人： Atsushi Miwa ,  Tetsuya Yoshino ,  Tatsushi Osawa ,  Teruyuki Sakai ,  Toshiyuki Shimizu ,  Yasunari Fujiwara

    IPC分类号： C07D215/38 ,  C07D239/72 ,  A61K31/47

    CPC分类号： C07D215/233 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02

    摘要： An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(═O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.

    摘要翻译： 本发明的目的是提供对FGF受体家族的自磷酸化具有抑制活性的新型化合物，并且当口服或经受干预时可抑制癌细胞的生长。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂合物：其中X表示CH或N; Z表示O或S; Q表示NR10，CR11R2，羰基，O，S（-O）m，其中m为0至2，或脲; R 1至R 3各自独立地表示其中烷基和烷氧基任选被取代的H，OH，卤素，硝基，氨基，烷基，烷氧基等; R4表示H; R5至R8各自独立地表示H，卤素，烷基或烷氧基; 并且R 9表示任选取代的碳环或杂环基。

    Quinoline derivatives and quinazoline derivatives
    7.
    发明授权
    Quinoline derivatives and quinazoline derivatives 失效
    喹啉衍生物和喹唑啉衍生物

    公开(公告)号：US06797823B1

    公开(公告)日：2004-09-28

    申请号：US09889858

    申请日：2001-07-23

    申请人： Kazuo Kubo ,  Yasunari Fujiwara ,  Toshiyuki Isoe

    发明人： Kazuo Kubo ,  Yasunari Fujiwara ,  Toshiyuki Isoe

    IPC分类号： C07D23988

    CPC分类号： C07D215/233 ,  C07D231/12 ,  C07D233/56 ,  C07D239/88 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12

    摘要： An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.

    摘要翻译： 本发明的目的是提供具有抗肿瘤活性并且不改变细胞毒性的化合物。 公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂合物和包含所述化合物的药物组合物：其中X和Z各自独立地表示CH或N; R 1至R 3代表H，取代的烷氧基，未被取代的烷氧基等; R 4表示H; R 5至R 8表示H，卤素，烷基，烷氧基，烷硫基，硝基或氨基，条件是R 5至R 8不同时表示H; R 9和R 10代表H，烷基或烷基羰基; R 11表示烷基，烯基，炔基或芳烷基。

    Quinoline derivatives and quinazoline derivatives
    8.
    发明申请
    Quinoline derivatives and quinazoline derivatives 审中-公开
    喹啉衍生物和喹唑啉衍生物

    公开(公告)号：US20070027318A1

    公开(公告)日：2007-02-01

    申请号：US11526739

    申请日：2006-09-26

    申请人： Kazuo Kubo ,  Yasunari Fujiwara ,  Toshiyuki Isoe

    发明人： Kazuo Kubo ,  Yasunari Fujiwara ,  Toshiyuki Isoe

    IPC分类号： C07D413/02 ,  C07D403/02 ,  C07D401/02

    CPC分类号： C07D215/233 ,  C07D231/12 ,  C07D233/56 ,  C07D239/88 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12

    摘要： An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.

    摘要翻译： 本发明的目的是提供具有抗肿瘤活性并且不改变细胞毒性的化合物。 公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂合物和包含所述化合物的药物组合物：其中X和Z各自独立地表示CH或N; R 1至R 3代表H，取代的烷氧基，未取代的烷氧基等; R 4表示H; R 5至R 8表示H，卤素，烷基，烷氧基，烷硫基，硝基或氨基，条件是R 5至R“ > 8 不同时代表H; R 9和R 10代表H，烷基或烷基羰基; R 11表示烷基，烯基，炔基或芳烷基。